The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations
commonly involve co-deletion of adjacent genes, including methylthioadenosine …

Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of
ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic …

Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in
a highly coordinated manner. More than 200 factors ensure correct modification, processing …

The coordinated integration of ribosomal RNA and protein into two functional ribosomal
subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly …

The formation of eukaryotic ribosomal subunits extends from the nucleolus to the cytoplasm
and entails hundreds of assembly factors. Despite differences in the pathways of ribosome …

Proper regulation of ribosome biosynthesis is mandatory for cellular adaptation, growth and
proliferation. Ribosome biogenesis is the most energetically demanding cellular process …

Final maturation of eukaryotic ribosomes occurs in the cytoplasm and requires the
sequential removal of associated assembly factors and processing of the immature 20S pre …

Glioblastoma, the most common primary malignant brain tumor, is incurable with current
therapies. Genetic and molecular analyses demonstrate that glioblastomas frequently …