miRNAs as potential game-changers in bone diseases: Future medicinal and clinical Uses

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

Wnt/β-catenin-driven EMT regulation in human cancers

W Xue, L Yang, C Chen, M Ashrafizadeh, Y Tian… - Cellular and Molecular …, 2024 - Springer
Metastasis accounts for 90% of cancer-related deaths among the patients. The
transformation of epithelial cells into mesenchymal cells with molecular alterations can occur …

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

Y Wang, L Zheng, W Shang, Z Yang, T Li… - Cell Death & …, 2022 - nature.com
The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in
gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically …

Pediatric adrenocortical carcinoma

M Ilanchezhian, DG Varghese, JW Glod… - Frontiers in …, 2022 - frontiersin.org
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy of the adrenal gland with
an unfavorable prognosis. It is rare in the pediatric population, with an incidence of 0.2-0.3 …

Drug repurposing—an emerging strategy in cancer therapeutics

KS Turabi, A Deshmukh, S Paul, D Swami… - Naunyn-Schmiedeberg's …, 2022 - Springer
Cancer is a complex disease affecting millions of people around the world. Despite
advances in surgical and radiation therapy, chemotherapy continues to be an important …

Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition

MM Amin, GEDA Abuo-Rahma, MSA Shaykoon… - Bioorganic …, 2023 - Elsevier
The present study established thirteen novel 8-hydroxyquinoline/chalcone hybrids 3a–m of
hopeful anticancer activity. According to NCI screening and MTT assay results, compounds …

Nobiletin in cancer therapy; mechanisms and therapy perspectives

R Moazamiyanfar, S Rezaei… - Current …, 2023 - ingentaconnect.com
Cancer has remained to be one of the major challenges in medicine and regarded as the
second leading cause of death worldwide. Different types of cancer may resist anti-cancer …

Update on biology and genomics of adrenocortical carcinomas: rationale for emerging therapies

AM Lerario, DR Mohan, GD Hammer - Endocrine Reviews, 2022 - academic.oup.com
The adrenal glands are paired endocrine organs that produce steroid hormones and
catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal …

Targeting Wnt/β-catenin pathways in primary liver tumours: from microenvironment signaling to therapeutic agents

F Selvaggi, T Catalano, R Cotellese, GM Aceto - Cancers, 2022 - mdpi.com
Simple Summary Human primary liver cancers have a poor prognosis. At present, there are
limited treatment alternatives, and to understand the molecular aspects of liver …

Non-coding RNA-based therapeutics in cancer therapy: An emphasis on Wnt/β-catenin control

A Taheriazam, SD Bayanzadeh, MH Farahani… - European Journal of …, 2023 - Elsevier
Non-coding RNA transcripts are RNA molecules that have mainly regulatory functions and
they do not encode proteins. microRNAs (miRNAs), lncRNAs and circRNAs are major types …