Tetrahydrobiopterin in cell function and death mechanisms

J Vasquez-Vivar, Z Shi, S Tan - Antioxidants & redox signaling, 2022 - liebertpub.com
Significance: Tetrahydrobiopterin (BH4) is most well known as a required cofactor for
enzymes regulating cellular redox homeostasis, aromatic amino acid metabolism, and …

GCH1: GTP cyclohydroxylase1: Role in neurodegenerative diseases

P Gupta, R Kumar - Gene, 2023 - Elsevier
GCH1 gene provides directions for the synthesis of GTP cyclohydrolase 1 which regulates
the formation of Tetrahydrobiopterin (BH4). BH4 is a crucial cofactor for essential …

Beyond HRV: attractor reconstruction using the entire cardiovascular waveform data for novel feature extraction

PJ Aston, MI Christie, YH Huang… - Physiological …, 2018 - iopscience.iop.org
Advances in monitoring technology allow blood pressure waveforms to be collected at
sampling frequencies of 250–1000 Hz for long time periods. However, much of the raw data …

Use of biotelemetry to define physiology-based deterioration thresholds in a murine cecal ligation and puncture model of sepsis

AJ Lewis, D Yuan, X Zhang, DC Angus… - Critical care …, 2016 - journals.lww.com
Objectives: Murine models of critical illness are commonly used to test new therapeutic
interventions. However, these interventions are often administered at fixed time intervals …

l-Phenylalanine Restores Vascular Function in Spontaneously Hypertensive Rats Through Activation of the GCH1-GFRP Complex

L Heikal, A Starr, D Hussein, J Prieto-Lloret… - JACC: Basic to …, 2018 - jacc.org
Reduced nitric oxide (NO) bioavailability correlates with impaired cardiovascular function.
NO is extremely labile and has been challenging to develop as a therapeutic agent …

[HTML][HTML] Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension

S Chuaiphichai, A Starr, M Nandi, KM Channon… - Vascular …, 2016 - Elsevier
Overproduction of nitric oxide (NO) is thought to be a key mediator of the vascular
dysfunction and severe hypotension in patients with endotoxaemia and septic shock. The …

Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection—Protocol Optimization and Pitfalls

K Vujacic-Mirski, M Oelze, I Kuntic, M Kuntic… - Antioxidants, 2022 - mdpi.com
Tetrahydrobiopterin (BH4) is an essential cofactor of all nitric oxide synthase isoforms, thus
determination of BH4 levels can provide important mechanistic insight into diseases. We …

In Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repurposing Approaches towards the Discovery of Effective BH4 …

D Hussein - International Journal of Molecular Sciences, 2023 - mdpi.com
The GTP cyclohydrolase 1 enzyme (GTPCH1) is the rate-limiting enzyme of the
tetrahydrobiopterin (BH4) biosynthetic pathway. Physiologically, BH4 plays a crucial role as …

Validating the GTP‐cyclohydrolase 1‐feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches

D Hussein, A Starr, L Heikal, E McNeill… - British journal of …, 2015 - Wiley Online Library
Background and Purpose 6R‐L‐erythro‐5, 6, 7, 8‐tetrahydrobiopterin (BH 4) is an essential
cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous …

[图书][B] The role of inducible nitric oxide synthase in macrophage activation following acute lung injury

TN Golden - 2016 - search.proquest.com
Macrophage origin and activity is complex in response to acute lung injury. Inducible nitric
oxide synthase (iNOS) has a divergent role in the stages following intratracheal bleomycin …