Tetrahydrobiopterin in cell function and death mechanisms
J Vasquez-Vivar, Z Shi, S Tan - Antioxidants & redox signaling, 2022 - liebertpub.com
Significance: Tetrahydrobiopterin (BH4) is most well known as a required cofactor for
enzymes regulating cellular redox homeostasis, aromatic amino acid metabolism, and …
enzymes regulating cellular redox homeostasis, aromatic amino acid metabolism, and …
GCH1: GTP cyclohydroxylase1: Role in neurodegenerative diseases
P Gupta, R Kumar - Gene, 2023 - Elsevier
GCH1 gene provides directions for the synthesis of GTP cyclohydrolase 1 which regulates
the formation of Tetrahydrobiopterin (BH4). BH4 is a crucial cofactor for essential …
the formation of Tetrahydrobiopterin (BH4). BH4 is a crucial cofactor for essential …
Beyond HRV: attractor reconstruction using the entire cardiovascular waveform data for novel feature extraction
Advances in monitoring technology allow blood pressure waveforms to be collected at
sampling frequencies of 250–1000 Hz for long time periods. However, much of the raw data …
sampling frequencies of 250–1000 Hz for long time periods. However, much of the raw data …
Use of biotelemetry to define physiology-based deterioration thresholds in a murine cecal ligation and puncture model of sepsis
AJ Lewis, D Yuan, X Zhang, DC Angus… - Critical care …, 2016 - journals.lww.com
Objectives: Murine models of critical illness are commonly used to test new therapeutic
interventions. However, these interventions are often administered at fixed time intervals …
interventions. However, these interventions are often administered at fixed time intervals …
l-Phenylalanine Restores Vascular Function in Spontaneously Hypertensive Rats Through Activation of the GCH1-GFRP Complex
Reduced nitric oxide (NO) bioavailability correlates with impaired cardiovascular function.
NO is extremely labile and has been challenging to develop as a therapeutic agent …
NO is extremely labile and has been challenging to develop as a therapeutic agent …
[HTML][HTML] Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension
S Chuaiphichai, A Starr, M Nandi, KM Channon… - Vascular …, 2016 - Elsevier
Overproduction of nitric oxide (NO) is thought to be a key mediator of the vascular
dysfunction and severe hypotension in patients with endotoxaemia and septic shock. The …
dysfunction and severe hypotension in patients with endotoxaemia and septic shock. The …
Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection—Protocol Optimization and Pitfalls
Tetrahydrobiopterin (BH4) is an essential cofactor of all nitric oxide synthase isoforms, thus
determination of BH4 levels can provide important mechanistic insight into diseases. We …
determination of BH4 levels can provide important mechanistic insight into diseases. We …
In Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repurposing Approaches towards the Discovery of Effective BH4 …
D Hussein - International Journal of Molecular Sciences, 2023 - mdpi.com
The GTP cyclohydrolase 1 enzyme (GTPCH1) is the rate-limiting enzyme of the
tetrahydrobiopterin (BH4) biosynthetic pathway. Physiologically, BH4 plays a crucial role as …
tetrahydrobiopterin (BH4) biosynthetic pathway. Physiologically, BH4 plays a crucial role as …
Validating the GTP‐cyclohydrolase 1‐feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches
Background and Purpose 6R‐L‐erythro‐5, 6, 7, 8‐tetrahydrobiopterin (BH 4) is an essential
cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous …
cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous …
[图书][B] The role of inducible nitric oxide synthase in macrophage activation following acute lung injury
TN Golden - 2016 - search.proquest.com
Macrophage origin and activity is complex in response to acute lung injury. Inducible nitric
oxide synthase (iNOS) has a divergent role in the stages following intratracheal bleomycin …
oxide synthase (iNOS) has a divergent role in the stages following intratracheal bleomycin …