The blood–brain barrier (BBB) restricts the transport of potential therapeutic moieties to the
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …

The central nervous system (CNS) encompasses the brain and spinal cord and is
considered the processing center and the most vital part of human body. The central …

Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly
specialized brain microvascular endothelial cells, a major component of the BBB, express …

Noninvasive, targeted drug delivery to the brain can be achieved using transcranial focused
ultrasound (FUS), which transiently increases the permeability of the blood–brain barrier …

Restricted drug entry to the brain that is closely associated with the existence of the blood
brain barrier (BBB) has limited the accessibility of most potential active therapeutic …

The blood–brain barrier (BBB) is the main obstacle to the effective delivery of therapeutic
agents to the brain, compromising treatment efficacy for a variety of neurological disorders …

Ischemic stroke is the leading cause of mortality and long-term disability worldwide.
Disruption of the blood–brain barrier (BBB) is a prominent pathophysiological mechanism …

Glioblastoma multiforme (GBM) is a very common type of “incurable” malignant brain tumor.
Although many treatment options are currently available, most of them eventually fail due to …

Intracranial malignancies, such as primary brain cancers and brain-localized metastases
derived from peripheral cancers, are particularly difficult to treat with therapeutic agents …

Introduction: Glioblastomas (GBM) are the most common and aggressive primary malignant
brain tumors in adults. The blood brain barrier (BBB) is a major limitation reducing efficacy of …