A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork …

M Deiana, JM Andrés Castán, P Josse… - Nucleic acids …, 2023 - academic.oup.com
Photodynamic therapy (PDT) ideally relies on the administration, selective accumulation and
photoactivation of a photosensitizer (PS) into diseased tissues. In this context, we report a …

Site-selected thionated benzothioxanthene chromophores as heavy-atom-free small-molecule photosensitizers for photodynamic therapy

M Deiana, P Josse, C Dalinot, A Osmolovskyi… - Communications …, 2022 - nature.com
Photodynamic therapy is a clinically approved anticancer modality that employs a light-
activated agent (photosensitizer) to generate cytotoxic reactive oxygen species (ROS) …

Driving Triplet State Population in Benzothioxanthene Imide Dyes: Let's twist!

D Puchán Sánchez, P Josse, N Plassais… - … A European Journal, 2024 - Wiley Online Library
Controlling the formation of photoexcited triplet states is critical for many (photo) chemical
and physical applications. Here, we demonstrate that a permanent out‐of‐plane distortion of …

Key role of electronic and structural properties in regulating intersystem crossing: an in-depth investigation on naphthalene-diimide triads for thermally activated …

F Coppola, M Hussain, J Zhao… - The Journal of …, 2024 - ACS Publications
We report an extensive theoretical investigation of the photophysical properties of new
carbazole core-substituted naphthalene-diimide dyes to elucidate the effects of different …

Benzothioxanthene dicarboximide as a tuneable electrogenerated chemiluminescence dye

AL Dauphin, JM Andrés Castán, J Yu… - …, 2022 - Wiley Online Library
Overlooked for years, the promising benzothioxanthene dicarboximide (BTXI) structure is
nonetheless known to be an excellent fluorophore. As a further step towards the exploration …

Thiochromenocarbazole imide-based photosensitizers decorated with carbonic anhydrase inhibitors for the targeted treatment of hypoxic tumours

A Merabti, DP Sánchez, A Nocentini, LMA Ali… - Materials …, 2024 - pubs.rsc.org
PDT has gained growing interest as a prospective approach for cancer therapy, thanks to its
minimal invasiveness and low systemic toxicity, making it a promising therapeutic option …

Exploring the concept of dimerization-induced intersystem crossing: At the origins of spin–orbit coupling selection rules

LA Galán, JM Andrés Castán, C Dalinot… - The Journal of …, 2021 - ACS Publications
Singlet–triplet interconversions (intersystem crossing, ISC) in organic molecules are at the
basis of many important processes in cutting-edge photonic applications (organic light …

Expanding the Use of Benzothioxanthene Imides to Photochemistry: Eco‐Friendly Aerobic Oxidation of Sulfides to Sulfoxides

SK Serviou, PL Gkizis, DP Sánchez, N Plassais… - …, 2024 - Wiley Online Library
The sulfoxide moiety is one of the most commonly utilized groups in pharmaceutical and
industrial chemistry. The need for sustainability and easy accessibility to sulfoxide moieties …

Synthesis, characterization and use of benzothioxanthene imide based dimers

JMA Castán, C Dalinot, S Dayneko, LA Galan… - Chemical …, 2020 - pubs.rsc.org
The synthesis of benzothioxanthene imide based dimers is reported herein. Subtle chemical
modifications were carried out and their impact on the optical and electrochemical properties …

Metal‐Free Benzothioxanthene Imide Based Dyes for Organic Light‐Emitting Electrochemical Cells

KK Leong, HJ Kim, K Morice, P Josse… - Advanced Optical …, 2024 - Wiley Online Library
Two synthetic organic dyes of the Benzothioxanthene imide (BTI) family are explored as a
promising electroactive material for organic light‐emitting electrochemical cells (LECs). The …