Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …

Background: Among patients having noncardiac surgery, perioperative hemodynamic
abnormalities are associated with vascular complications. Uncertainty remains about what …

The public enquiry into the mass casualty incident at the Manchester Arena in the UK in
which 23 people died and over 1000 were injured, identified the need for timely …

Peri‐operative cardiovascular events occur in up to 3% of patients undergoing non‐cardiac
surgery. Accurate cardiovascular risk assessment is important in the peri‐operative setting …

Background Prediction tools for various intraoperative bleeding events remain scarce. We
aim to develop machine learning-based models and identify the most important predictors …

In this pre-specified sub-study of the POISE-3 trial, we examined the effect of a perioperative
hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of …

Background The relationship between postoperative adverse events and blood pressures in
the preoperative period remains poorly understood. This study tested the hypothesis that …

Background Vasoplegic syndrome (VS) is a constellation of signs characterized by
hypotension (typically mean arterial pressure [MAP]< 50 mm Hg without vasopressor …

Perioperative myocardial injury is a relatively common complication after noncardiac surgery
associated with significant morbidity and mortality. It is frequently driven by physiologic …

Study design The STOP-or-NOT trial (NCT03374449) 11, 12 is an investigator-initiated,
multicentre, open-label, randomized controlled trial conducted at 40 French hospitals …