The spinal dorsal horn receives input from primary afferent axons, which terminate in a
modality-specific fashion in different laminae. The incoming somatosensory information is …

The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron
populations that are critical to process sensory information. Neurons in these areas are …

Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This
information is processed by the spinal cord; however, the way in which this occurs is still …

The lateral parabrachial nucleus (LPBN) is known to relay noxious information to the
amygdala for processing affective responses. However, it is unclear whether the LPBN …

Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for
minutes to hours. However, the neural basis for this effect is unclear, and the underlying …

The gate control theory of pain proposes that inhibitory neurons of the spinal dorsal horn
exert critical control over the relay of nociceptive signals to higher brain areas. Here we …

Pain is a percept of critical importance to our daily survival. In most cases, it serves both an
adaptive function by helping us respond appropriately in a potentially hostile environment …

The anterolateral tract (ALT), which originates from neurons in lamina I and the deep dorsal
horn, represents a major ascending output through which nociceptive information is …

Since 1967, spinal cord stimulation (SCS) has been used to manage chronic intractable
pain of the trunk and limbs. Compared to traditional high-intensity, low-frequency (< 100 Hz) …

Around a quarter of neurons in laminae I–II of the dorsal horn are inhibitory interneurons.
These play an important role in modulating somatosensory information, including that …