The reconstruction and analysis of genome-scale metabolic models constitutes a powerful
systems biology approach, with applications ranging from basic understanding of genotype …

The cultivated meat industry, also known as cell‐based meat, cultured meat, lab‐grown
meat, or meat alternatives, is a growing field that aims to generate animal tissues ex‐vivo in …

In the production of cell-based meat, it is desirable to reduce animal-derived materials as
much as possible to meet the challenges of sustainability. Here, we demonstrate the “cell …

Immune checkpoint inhibitors (ICIs) have achieved huge clinical success. However, many
still have limited response rates, and are prohibitively costly. There is a need for effective …

The control of nutrient availability is critical to large‐scale manufacturing of biotherapeutics.
However, the quantification of proteinogenic amino acids is time‐consuming and thus is …

In order to meet the rising demand for biologics and become competitive on the developing
biosimilar market, there is a need for process intensification of biomanufacturing processes …

Cultured meat has the potential to provide a complementary meat industry with reduced
environmental, ethical, and health impacts. However, major technological challenges …

Genome-scale models of metabolism (GEMs) are key computational tools for the systems-
level study of metabolic networks. Here, we describe the" GEM life cycle," which we …

Recently, spICP-MS analyses of microplastics have demonstrated that the detection
capabilities of ICP-MS are sufficient to determine the size and composition of such materials …

Flux balance analysis (FBA) is currently the standard method to compute metabolic fluxes in
genome-scale networks. Several FBA extensions employing diverse objective functions …