Improving translation of animal models of addiction and relapse by reverse translation
Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …
animal models, including escalation of drug intake, punished drug seeking and taking …
The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex
AO Ceceli, CW Bradberry, RZ Goldstein - Neuropsychopharmacology, 2022 - nature.com
A growing preclinical and clinical body of work on the effects of chronic drug use and drug
addiction has extended the scope of inquiry from the putative reward-related subcortical …
addiction has extended the scope of inquiry from the putative reward-related subcortical …
In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids
Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are
involved in movement control and reward-related cognition. In Parkinson's disease …
involved in movement control and reward-related cognition. In Parkinson's disease …
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
RZ Goldstein, ND Volkow - Nature reviews neuroscience, 2011 - nature.com
The loss of control over drug intake that occurs in addiction was initially believed to result
from disruption of subcortical reward circuits. However, imaging studies in addictive …
from disruption of subcortical reward circuits. However, imaging studies in addictive …
The development and maintenance of drug addiction
What is the defining property of addiction? We dust off a several-decades-long debate about
the relative importance of two forms of reinforcement—positive reinforcement, subjectively …
the relative importance of two forms of reinforcement—positive reinforcement, subjectively …
New developments in brain research of internet and gaming disorder
There is evidence that the neural mechanisms underlying Internet Gaming Disorder (IGD)
resemble those of drug addiction. Functional Magnetic Resonance Imaging (fMRI) studies of …
resemble those of drug addiction. Functional Magnetic Resonance Imaging (fMRI) studies of …
Cortico-striatal-thalamic loop circuits of the orbitofrontal cortex: promising therapeutic targets in psychiatric illness
Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …
human behaviors such as evaluation, affect regulation and reward-based decision-making …
Predictive reward signal of dopamine neurons
W Schultz - Journal of neurophysiology, 1998 - journals.physiology.org
Schultz, Wolfram. Predictive reward signal of dopamine neurons. J. Neurophysiol. 80: 1–27,
1998. The effects of lesions, receptor blocking, electrical self-stimulation, and drugs of abuse …
1998. The effects of lesions, receptor blocking, electrical self-stimulation, and drugs of abuse …
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
KC Berridge, TE Robinson - Brain research reviews, 1998 - Elsevier
What roles do mesolimbic and neostriatal dopamine systems play in reward? Do they
mediate the hedonic impact of rewarding stimuli? Do they mediate hedonic reward learning …
mediate the hedonic impact of rewarding stimuli? Do they mediate hedonic reward learning …
Getting formal with dopamine and reward
W Schultz - Neuron, 2002 - cell.com
Recent neurophysiological studies reveal that neurons in certain brain structures carry
specific signals about past and future rewards. Dopamine neurons display a short-latency …
specific signals about past and future rewards. Dopamine neurons display a short-latency …