[HTML][HTML] NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology

A Vermot, I Petit-Härtlein, SME Smith, F Fieschi - Antioxidants, 2021 - mdpi.com
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

[HTML][HTML] Vitamin C and immune function

AC Carr, S Maggini - Nutrients, 2017 - mdpi.com
Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its
ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic …

[HTML][HTML] The emerging role of vitamin C as a treatment for sepsis

MG Kashiouris, M L'Heureux, CA Cable, BJ Fisher… - Nutrients, 2020 - mdpi.com
Sepsis, a life-threatening organ dysfunction due to a dysregulated host response to
infection, is a leading cause of morbidity and mortality worldwide. Decades of research have …

[HTML][HTML] Mitochondrial dysfunction in cancer

ML Boland, AH Chourasia, KF Macleod - Frontiers in oncology, 2013 - frontiersin.org
A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth
and tumorigenesis is emerging beyond Warburg as an area of research that is under …

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

K Bedard, KH Krause - Physiological reviews, 2007 - journals.physiology.org
For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment

B Halliwell - Drugs & aging, 2001 - Springer
Free radicals and other so-called 'reactive species' are constantly produced in the brain in
vivo. Some arise by 'accidents of chemistry', an example of which may be the leakage of …

Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness

KA Conklin - Integrative cancer therapies, 2004 - journals.sagepub.com
Antineoplastic agents induce oxidative stress in biological systems. During cancer
chemotherapy, oxidative stress-induced lipid peroxidation generates numerous electrophilic …

The homeostatic role of hydrogen peroxide, superoxide anion and nitric oxide in the vasculature

TJ Costa, PR Barros, C Arce, JD Santos… - Free Radical Biology …, 2021 - Elsevier
Reactive oxygen and nitrogen species are produced in a wide range of physiological
reactions that, at low concentrations, play essential roles in living organisms. There is a …

Living and dying for inflammation: neutrophils, eosinophils, basophils

B Geering, C Stoeckle, S Conus, HU Simon - Trends in immunology, 2013 - cell.com
Neutrophils, eosinophils, and basophils play essential roles during microbe-induced and
sterile inflammation. The severity of such inflammatory processes is controlled, at least in …

Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and …

K Irani - Circulation research, 2000 - Am Heart Assoc
Reactive oxygen species (ROS) have been traditionally regarded as toxic byproducts of
aerobic metabolism. However, ROS can also act as intracellular signaling molecules in …