Museum of spatial transcriptomics

L Moses, L Pachter - Nature methods, 2022 - nature.com
The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

MicroRNA-mediated regulation of glucose and lipid metabolism

P Agbu, RW Carthew - Nature reviews Molecular cell biology, 2021 - nature.com
In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …

Cartilage homeostasis and osteoarthritis

Y Fujii, L Liu, L Yagasaki, M Inotsume, T Chiba… - International Journal of …, 2022 - mdpi.com
Healthy limb joints are important for maintaining health and attaining longevity.
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …

Rationally engineered nucleic acid architectures for biosensing applications

M Xiao, W Lai, T Man, B Chang, L Li… - Chemical …, 2019 - ACS Publications
Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …

MicroRNA: function, detection, and bioanalysis

H Dong, J Lei, L Ding, Y Wen, H Ju, X Zhang - Chemical reviews, 2013 - ACS Publications
Mature microRNAs (miRNAs) are a class of evolutionally conserved, single-stranded, small
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …

MicroRNA profiling: approaches and considerations

CC Pritchard, HH Cheng, M Tewari - Nature Reviews Genetics, 2012 - nature.com
MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of
thousands of genes in a broad range of organisms in both normal physiological contexts …

Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity

B Xu, Y Zhang, XF Du, J Li, HX Zi, JW Bu, Y Yan, H Han… - Cell research, 2017 - nature.com
Vascular integrity helps maintain brain microenvironment homeostasis, which is critical for
the normal development and function of the central nervous system. It is known that neural …

dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers

Z Yang, L Wu, A Wang, W Tang, Y Zhao… - Nucleic acids …, 2017 - academic.oup.com
MicroRNAs (miRNAs) are often deregulated in cancer and are thought to play an important
role in cancer development. Large amount of differentially expressed miRNAs have been …

KRAS-dependent sorting of miRNA to exosomes

DJ Cha, JL Franklin, Y Dou, Q Liu, JN Higginbotham… - Elife, 2015 - elifesciences.org
Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter
the tumor microenvironment. To test whether exosomal RNAs also contribute to changes in …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …