The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition resulting
from direct and indirect insults to the lung. It is characterized by disruption of the endothelial …

Publisher Summary This chapter reviews the role of cytokines in the pathogenesis of sepsis.
The various models for sepsis are also discussed, including the human models and animal …

IL-6 is induced often together with the proinflammatory cytokines TNFalpha and IL-1 in many
alarm conditions, and circulating IL-6 plays an important role in the induction of acute phase …

Acute inflammatory lung injury is often a delayed complication of critical illness and is
associated with increased mortality. High mobility group-1 (HMG-1) protein, in addition to its …

IL-17 is a cytokine implicated in the regulation of inflammation. We investigated the role of
this cytokine in neutrophil recruitment using a model of LPS-induced lung inflammation in …

There is conflicting evidence in the literature as to the predominant mechanism and also the
compositional element (s) that drives the pulmonary inflammatory response of ambient …

Increasing evidence supports the involvement of inflammation in the early phases of
atherogenesis. Recruitment of leukocytes within the vascular wall, controlled by …

NF-κB binding sites are present in the promoter regions of many acute phase and
inflammatory response genes, suggesting that NF-κB plays an important role in the initiation …

To study the in vivo role of alveolar macrophages (AM) in gram-negative bacterial
pneumonia in mice, AM were eliminated by the intratracheal (it) administration of …

TLRs function as pattern recognition receptors in mammals and play an essential role in the
recognition of microbial components. We found that the injection of …