Bone is the most frequent site of metastasis of the most common cancers in men and
women. Bone metastasis incidence has been steadily increasing over the years, mainly …

Though both neuropathy and fibromyalgia are serious complications that cause widespread
pain, distinguishing between the two in order to provide adequate care is difficult. Metabolic …

The diterpenoid alkaloids are a family of extremely important natural products that have long
been a research hotspot due to their myriad of intricate structures and diverse biological …

Substance P (SP) regulates multiple biological processes through its high-affinity neurokinin-
1 receptor (NK-1R). While the SP/NK-1R signaling axis is involved in the pathogenesis of …

Lappaconitine is a representative C18-diterpenoid alkaloid extracted from Aconitum
sinomontanum Nakai and has been prescribed as a pain relief medicine in China for more …

Bone cancer pain (BCP) is a common complication with inadequate management in patients
suffering from advanced cancer. Histone deacetylase inhibitors showed significant …

Ethnopharmacological relevance As a folk medicine, Aconitum sinomontanum Nakai
(Ranunculaceae) a perennial herbaceous flowering plant, is a widely used traditional …

Due to the efficacy and tolerability of the available drugs, the current treatment for cancer-
induced bone pain (CIBP) is not considered ideal, and new drugs are required for better …

Convenient and efficient routes to construct hybrid molecules containing diterpene alkaloid
lappaconitine and pyrimidine fragments are reported. One route takes place via first …

Quantitative evaluation of analgesic efficacy improves understanding of the antinociceptive
mechanisms of new analgesics and provides important guidance for their development …