Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …

Ulcerative colitis (UC) specifically affects the colon and rectum through multifactorial
mechanisms associated with genetic alterations, environmental factors, microbiota, and …

How intestinal microbes regulate metabolic syndrome is incompletely understood. We show
that intestinal microbiota protects against development of obesity, metabolic syndrome, and …

When helper T (TH) cell polarization was initially described three decades ago, the TH cell
universe grew dramatically. New subsets were described based on their expression of few …

T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining
immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in …

Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven
by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17 …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

Diagnosis and management of axial spondyloarthritis (axSpA) has vastly improved over the
past two decades. With advances in the discernment of immunopathogenesis of this …

Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract
and can be classified into 2 main clinical phenomena: Crohn's disease (CD) and ulcerative …

Crohn's disease (CD) is a chronic relapsing disorder of the gastrointestinal tract and
represents one of the main entities of inflammatory bowel disease (IBD). CD affects …