Host invasion by pathogenic amoebae: epithelial disruption by parasite proteins

A Betanzos, C Bañuelos, E Orozco - Genes, 2019 - mdpi.com
The epithelium represents the first and most extensive line of defence against pathogens,
toxins and pollutant agents in humans. In general, pathogens have developed strategies to …

Proteases from Entamoeba spp. and Pathogenic Free‐Living Amoebae as Virulence Factors

J Serrano-Luna, C Piña-Vázquez… - Journal of tropical …, 2013 - Wiley Online Library
The standard reference for pathogenic and nonpathogenic amoebae is the human parasite
Entamoeba histolytica; a direct correlation between virulence and protease expression has …

[HTML][HTML] Biological roles of cysteine proteinases in the pathogenesis of Trichomonas vaginalis

HM Hernández, R Marcet, J Sarracent - Parasite, 2014 - ncbi.nlm.nih.gov
Human trichomonosis, infection with Trichomonas vaginalis, is the most common non-viral
sexually transmitted disease in the world. The host-parasite interaction and …

Identification and characterization of alkaline serine protease from goat skin surface metagenome

PL Pushpam, T Rajesh, P Gunasekaran - AMB express, 2011 - Springer
Metagenomic DNA isolated from goat skin surface was used to construct plasmid DNA
library in Escherichia coli DH10B. Recombinant clones were screened for functional …

A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target

C He, GP Nora, EL Schneider, ID Kerr, E Hansell… - Journal of Biological …, 2010 - ASBMB
Entamoeba histolytica cysteine proteinases (EhCPs) play a key role in disrupting the colonic
epithelial barrier and the innate host immune response during invasion of E. histolytica, the …

Entamoeba histolytica EhCP112 Dislocates and Degrades Claudin-1 and Claudin-2 at Tight Junctions of the Intestinal Epithelium

P Cuellar, E Hernández-Nava… - Frontiers in cellular …, 2017 - frontiersin.org
During intestinal invasion, Entamoeba histolytica opens tight junctions (TJs) reflected by
transepithelial electrical resistance (TEER) dropping. To explore the molecular mechanisms …

Production of recombinant proteins from protozoan parasites

JA Fernández-Robledo, GR Vasta - Trends in parasitology, 2010 - cell.com
Although the past decade has witnessed sequencing from an increasing number of
parasites, modern high-throughput DNA sequencing technologies have the potential to …

A new cysteine protease allergen from Ambrosia trifida pollen: proforms and mature forms

XJ Ling, YJ Zhou, YS Yang, ZQ Xu, Y Wang, JL Sun… - Molecular …, 2022 - Elsevier
Giant ragweed (Ambrosia trifida) pollen is closely associated with respiratory allergy in late
summer and autumn, and the prevalence of giant ragweed pollen allergy progressively …

Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development

N Jasni, S Saidin, WW Kin, N Arifin, N Othman - Membranes, 2022 - mdpi.com
Entamoeba histolytica is a protozoan parasite that is the causative agent of amoebiasis. This
parasite has caused widespread infection in India, Africa, Mexico, and Central and South …

Adherens junctions and desmosomes are damaged by Entamoeba histolytica: Participation of EhCPADH complex and EhCP112 protease

E Hernández‐Nava, P Cuellar, P Nava… - Cellular …, 2017 - Wiley Online Library
Entamoeba histolytica trophozoites adhere to epithelium at the cell–cell contact and perturb
tight junctions disturbing the transepithelial electrical resistance. Behind tight junctions are …