Karyopherin-mediated nucleocytoplasmic transport
Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
RNA polymerase II C-terminal domain: tethering transcription to transcript and template
JL Corden - Chemical reviews, 2013 - ACS Publications
By definition the CTD consists of the amino acid sequences extending from the largest
subunit, RPO21 or RPB1 in yeast and POLR2A in human. Specifically the CTD consists of …
subunit, RPO21 or RPB1 in yeast and POLR2A in human. Specifically the CTD consists of …
Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation
Messenger RNA processing is coupled to RNA polymerase II (RNAPII) transcription through
coordinated recruitment of accessory proteins to the Rpb1 C-terminal domain (CTD) …
coordinated recruitment of accessory proteins to the Rpb1 C-terminal domain (CTD) …
Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes
The carboxy-terminal domain (CTD) of the large subunit of RNA polymerase II (Pol II)
comprises multiple heptapeptide repeats of the consensus Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6 …
comprises multiple heptapeptide repeats of the consensus Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6 …
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets
The transcription cycle of RNA polymerase II (RNAPII) is governed at multiple points by
opposing actions of cyclin-dependent kinases (CDKs) and protein phosphatases, in a …
opposing actions of cyclin-dependent kinases (CDKs) and protein phosphatases, in a …
Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya
S Borrmann, J Straimer, L Mwai, A Abdi, A Rippert… - Scientific reports, 2013 - nature.com
Early identification of causal genetic variants underlying antimalarial drug resistance could
provide robust epidemiological tools for timely public health interventions. Using a novel …
provide robust epidemiological tools for timely public health interventions. Using a novel …
Protein phosphatases of Saccharomyces cerevisiae
SR Offley, MC Schmidt - Current genetics, 2019 - Springer
The phosphorylation status of a protein is highly regulated and is determined by the
opposing activities of protein kinases and protein phosphatases within the cell. While much …
opposing activities of protein kinases and protein phosphatases within the cell. While much …
Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation
P Allepuz-Fuster, V Martínez-Fernández… - Nucleic acids …, 2014 - academic.oup.com
Abstract The Rpb4 and Rpb7 subunits of eukaryotic RNA polymerase II (RNAPII) participate
in a variety of processes from transcription, DNA repair, mRNA export and decay, to …
in a variety of processes from transcription, DNA repair, mRNA export and decay, to …
Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2
D Forget, AA Lacombe, P Cloutier… - Nucleic acids …, 2013 - academic.oup.com
Abstract The RNA polymerase II (RNAP II)-associated protein (RPAP) 2 has been
discovered through its association with various subunits of RNAP II in affinity purification …
discovered through its association with various subunits of RNAP II in affinity purification …
Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
I Fianu, C Dienemann, S Aibara, S Schilbach… - Communications …, 2021 - nature.com
Nuclear import of RNA polymerase II (Pol II) involves the conserved factor RPAP2. Here we
report the cryo-electron microscopy (cryo-EM) structure of mammalian Pol II in complex with …
report the cryo-electron microscopy (cryo-EM) structure of mammalian Pol II in complex with …