Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

The MYC gene which consists of 3 paralogs, C-MYC, N-MYC and L-MYC, is one of the most
frequently deregulated driver genes in human cancer. Because of its high prevalence of …

The MYC oncogene codes for a transcription factor that is overexpressed in many human
cancers. Here we show that MYC regulates the expression of two immune checkpoint …

Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

Although the MYC oncogene has been implicated in cancer, a systematic assessment of
alterations of MYC, related transcription factors, and co-regulatory proteins, forming the …

The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated
anabolic program in response to growth-promoting signals. Paradoxically, recent studies …

Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …

Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …

Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …