One of the earliest and best-recognized elements of atherosclerosis is its close relationship
with circulating LDL (low-density lipoprotein). There is convincing evidence that LDL …

Acute myocardial infarction (AMI) is the single leading cause of mortality and morbidity
worldwide. A key component of AMI therapy is the timely reopening of occluded vessels to …

Inflammation is a complex pathophysiological process underlying many clinical conditions.
Platelets contribute to the thrombo‐inflammatory response. Platelet P2Y12 receptors amplify …

Background: Platelets have distinct roles in the vascular system in that they are the major
mediator of thrombosis, critical for restoration of tissue integrity, and players in vascular …

Rationale: Myocardial infarction and stroke are leading causes of morbidity/mortality. The
typical underlying pathology is the formation of thrombi/emboli and subsequent vessel …

Magnetic resonance imaging (MRI) is a powerful and indispensable tool in medical
research, clinical diagnosis, and patient care due to its high spatial resolution and non …

Ischaemic heart disease evokes a complex immune response. However, tools to track the
systemic behaviour and dynamics of leukocytes non-invasively in vivo are lacking. Here, we …

Platelets are clearly central to thrombosis and hemostasis. In addition, more recently,
evidence has emerged for non-hemostatic roles of platelets including inflammatory and …

Preconditioning, postconditioning, and remote conditioning of the myocardium enhance the
ability of the heart to withstand a prolonged ischemia/reperfusion insult and the potential to …

Myocardial ischemia-reperfusion (MI/R) injury is a complication in vascular reperfusion
therapy for MI, occurring in approximately 60% of patients. Ferroptosis is an important …