[HTML][HTML] Best practices for single-cell analysis across modalities
Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
TCR-engineered T cell therapy in solid tumors: State of the art and perspectives
E Baulu, C Gardet, N Chuvin, S Depil - Science Advances, 2023 - science.org
T cell engineering has changed the landscape of cancer immunotherapy. Chimeric antigen
receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell …
receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell …
[PDF][PDF] SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19
Over the past year, numerous studies in the peer reviewed and preprint literature have
reported on the virological, epidemiological and clinical characteristics of the coronavirus …
reported on the virological, epidemiological and clinical characteristics of the coronavirus …
[PDF][PDF] SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans
PA Mudd, AA Minervina, MV Pogorelyy, JS Turner… - Cell, 2022 - cell.com
SARS-CoV-2 mRNA vaccines induce robust anti-spike (S) antibody and CD4+ T cell
responses. It is not yet clear whether vaccine-induced follicular helper CD4+ T (T FH) cell …
responses. It is not yet clear whether vaccine-induced follicular helper CD4+ T (T FH) cell …
[PDF][PDF] Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
[PDF][PDF] Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy
C Krishna, RG DiNatale, F Kuo, RM Srivastava… - Cancer cell, 2021 - cell.com
Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrated, but the effect of
immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here …
immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here …
[HTML][HTML] Can we predict T cell specificity with digital biology and machine learning?
Recent advances in machine learning and experimental biology have offered breakthrough
solutions to problems such as protein structure prediction that were long thought to be …
solutions to problems such as protein structure prediction that were long thought to be …
[HTML][HTML] Neoantigen quality predicts immunoediting in survivors of pancreatic cancer
Cancer immunoediting is a hallmark of cancer that predicts that lymphocytes kill more
immunogenic cancer cells to cause less immunogenic clones to dominate a population …
immunogenic cancer cells to cause less immunogenic clones to dominate a population …
[HTML][HTML] SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells
Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high,
variant emergence has prompted booster immunizations. However, the effects of repeated …
variant emergence has prompted booster immunizations. However, the effects of repeated …
Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening
CD4+ T cells are critical to fighting pathogens, but a comprehensive analysis of human T-
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …