Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and
was first described in 1947 in Uganda following blood analyses of sentinel Rhesus …

The complexity of the human brain has made it difficult to study many brain disorders in
model organisms, highlighting the need for an in vitro model of human brain development …

The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in
fetal abnormalities and microcephaly. However, information about the underlying molecular …

Abstract Background N 6-methyladenosine (m 6 A) modification in mRNAs was recently
shown to be dynamically regulated, indicating a pivotal role in multiple developmental …

The classic view of cortical development, embodied in the radial unit hypothesis, highlights
the ventricular radial glia (vRG) scaffold as a key architectonic feature of the developing …

The size and extent of folding of the mammalian cerebral cortex are important factors that
influence a species' cognitive abilities and sensorimotor skills. Studies in various animal …

Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …