Metalloantimalarials
PF Salas, C Herrmann, C Orvig - Chemical reviews, 2013 - ACS Publications
Malaria is a worldwide neglected infectious disease that, despite decades of research
invested in its prevention and treatment, remains one of the main causes of mortality and …
invested in its prevention and treatment, remains one of the main causes of mortality and …
Medicinal utility of thiosemicarbazones with special reference to mixed ligand and mixed metal complexes: A Review
Thiosemicarbazone complexes possess structural diversity and variable bonding patterns
and potential biological implications and ion sensing abilities. The ability of the transition …
and potential biological implications and ion sensing abilities. The ability of the transition …
Synthesis, cytotoxicity and antimalarial activities of thiosemicarbazones and their nickel (II) complexes
S Savir, ZJ Wei, JWK Liew, I Vythilingam… - Journal of Molecular …, 2020 - Elsevier
A series of Schiff base metal complexes with the formulations [Ni (L1) 2](4),[Ni (L2) 2](5) and
[Ni (L3) 2](6),(where 1 or L1= fluorene-2-carboxaldehyde thiosemicarbazone, 2 or L2 …
[Ni (L3) 2](6),(where 1 or L1= fluorene-2-carboxaldehyde thiosemicarbazone, 2 or L2 …
Nickel (II) complexes with polyhydroxybenzaldehyde and O, N, S tridentate thiosemicarbazone ligands: Synthesis, cytotoxicity, antimalarial activity, and molecular …
S Savir, JWK Liew, I Vythilingam, YAL Lim… - Journal of Molecular …, 2021 - Elsevier
A series of Schiff base metal complexes with the formulations [Ni (L1) PPh 3] Cl (1),[Ni (L2)
PPh 3] Cl (2),[Ni (L3) PPh 3](3), and [Ni (L4) PPh 3](4)(where L1= 2, 3, 4 …
PPh 3] Cl (2),[Ni (L3) PPh 3](3), and [Ni (L4) PPh 3](4)(where L1= 2, 3, 4 …
Thiosemicarbazone derivatives: Design, synthesis and in vitro antimalarial activity studies
R Matsa, P Makam, M Kaushik, SL Hoti… - European Journal of …, 2019 - Elsevier
Different types of thiosemicarbazone derivatives were designed and tested for their Drug-
Like Molecular (DLM) nature by using Lipinski and Veber rules. Subsequently, compounds …
Like Molecular (DLM) nature by using Lipinski and Veber rules. Subsequently, compounds …
Synthesis, characterization, molecular modeling and biological activity of mixed ligand complexes of Cu (II), Ni (II) and Co (II) based on 1, 10-phenanthroline and novel …
M Aljahdali, AA El-Sherif - Inorganica Chimica Acta, 2013 - Elsevier
A combined experimental and computational study of novel mixed ligand Cu (II), Ni (II) and
Co (II) complexes of 2-(1-(2-phenyl-hydrazono)-propan-2-ylidene) hydrazine …
Co (II) complexes of 2-(1-(2-phenyl-hydrazono)-propan-2-ylidene) hydrazine …
The synthesis and antiparasitic activity of aryl-and ferrocenyl-derived thiosemicarbazone ruthenium (II)–arene complexes
M Adams, Y Li, H Khot, C De Kock, PJ Smith… - Dalton …, 2013 - pubs.rsc.org
A series of aryl-functionalized and ferrocenyl monothiosemicarbazone compounds (L1–L4)
were synthesized in moderate yields via a general Schiff-base condensation reaction. The …
were synthesized in moderate yields via a general Schiff-base condensation reaction. The …
Synthesis, DNA binding, and antiproliferative activity of novel acridine-thiosemicarbazone derivatives
SMV Almeida, EA Lafayette… - International journal of …, 2015 - mdpi.com
In this work, the acridine nucleus was used as a lead-compound for structural modification
by adding different substituted thiosemicarbazide moieties. Eight new (Z)-2-(acridin-9 …
by adding different substituted thiosemicarbazide moieties. Eight new (Z)-2-(acridin-9 …
Thiosemicarbazones with tyrosinase inhibitory activity
K Hałdys, R Latajka - MedChemComm, 2019 - pubs.rsc.org
Tyrosinase plays an essential role in melanogenesis. Excess production of melanin can be
a reason for hyperpigmentation skin disorders in mammals and enzymatic browning in plant …
a reason for hyperpigmentation skin disorders in mammals and enzymatic browning in plant …
Design, synthesis, and in vitro and in silico study of 1-benzyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors
Developing new anti-tyrosinase drugs seems crucial for the medical and industrial fields
since irregular melanin synthesis is linked to the resurgence of several skin conditions …
since irregular melanin synthesis is linked to the resurgence of several skin conditions …