Platinum (IV) and platinum (II) anticancer complexes with biologically active releasable ligands
P Štarha, R Křikavová - Coordination Chemistry Reviews, 2024 - Elsevier
The concept of multi-action octahedral platinum (IV) complexes is based on the rational
derivatization of anticancer square-planar platinum (II) compounds (eg, cisplatin or …
derivatization of anticancer square-planar platinum (II) compounds (eg, cisplatin or …
The current status in computational exploration of Pt (iv) prodrug activation by reduction
Octahedral PtIV complexes are considered highly promising candidates for overcoming
some shortcomings of clinically approved PtII drugs. PtIV compounds, owing to their inertia …
some shortcomings of clinically approved PtII drugs. PtIV compounds, owing to their inertia …
DFT Computational Analysis of the Mechanism of Action of Ru (II) Polypyridyl Complexes as Photoactivated Chemotherapy Agents: From Photoinduced Ligand …
Photoactivated chemotherapy (PACT) is a form of target-oriented cancer therapy that
exploits light of the proper wavelength to selectively activate the drug. Among the prodrugs …
exploits light of the proper wavelength to selectively activate the drug. Among the prodrugs …
Synthesis of a light-responsive platinum curcumin complex, chemical and biological investigations and delivery to tumor cells by means of polymeric nanoparticles
Platinum-based anticancer drugs are common in chemotherapy, but problems such as
systemic toxicity and acquired resistance of some tumors hamper their clinical applications …
systemic toxicity and acquired resistance of some tumors hamper their clinical applications …
Curcumin-based ionic Pt (ii) complexes: Antioxidant and antimicrobial activity
R Caligiuri, G Di Maio, N Godbert, F Scarpelli… - Dalton …, 2022 - pubs.rsc.org
A series of novel cationic curcumin-based Pt (II) complexes with neutral (N^ N) ligands and
triflate anions as counterions,[(N^ N) Pt (curc)] CF3SO3, 1–4, were synthesised and fully …
triflate anions as counterions,[(N^ N) Pt (curc)] CF3SO3, 1–4, were synthesised and fully …
Cytotoxic Pt (ii) complexes containing alizarin: a selective carrier for DNA metalation
R Caligiuri, L Massai, A Geri, L Ricciardi… - Dalton …, 2024 - pubs.rsc.org
Many efforts have been made in the last few decades to selectively transport antitumor
agents to their potential target sites with the aim to improve efficacy and selectivity. Indeed …
agents to their potential target sites with the aim to improve efficacy and selectivity. Indeed …
[HTML][HTML] Computational Exploration of the Mechanism of Action of a Sorafenib-Containing Ruthenium Complex as an Anticancer Agent for Photoactivated …
Ruthenium (II) polypyridyl complexes are being tested as potential anticancer agents in
different therapies, which include conventional chemotherapy and light-activated …
different therapies, which include conventional chemotherapy and light-activated …
G-quadruplex DNA selective targeting for anticancer therapy: a computational study of a novel Pt II monofunctional complex activated by adaptive binding
Targeting of G-quadruplex (GQ) nucleic acids, which are helical four-stranded structures
formed from guanine-rich nucleic acid sequences, has emerged in recent years as an …
formed from guanine-rich nucleic acid sequences, has emerged in recent years as an …
Noncovalent interactions of antitumor cycloplatinated complexes containing trifluoroacetate ligands as the leaving group with bovine serum albumin. Implications for …
MD Aseman, P Negaresh, Z Shojaeifard… - New Journal of …, 2023 - pubs.rsc.org
The biomolecular interactions of two previously reported cycloplatinated complexes,[Pt (C^
N)(SMe2)(OCOCF3)](C^ N= deprotonated benzo [h] quinoline (bhq), 1, or deprotonated 2 …
N)(SMe2)(OCOCF3)](C^ N= deprotonated benzo [h] quinoline (bhq), 1, or deprotonated 2 …