Preparing for the next viral threat with broad-spectrum antivirals
There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …
hundreds of viruses known to cause human disease and for the establishment of a …
Kinase inhibitors as underexplored antiviral agents
J García-Cárceles, E Caballero, C Gil… - Journal of medicinal …, 2021 - ACS Publications
Viral infections are a major health problem; therefore, there is an urgent need for novel
therapeutic strategies. Antivirals used to target proteins encoded by the viral genome usually …
therapeutic strategies. Antivirals used to target proteins encoded by the viral genome usually …
ELM—the Eukaryotic Linear Motif resource—2024 update
M Kumar, S Michael, J Alvarado-Valverde… - Nucleic acids …, 2024 - academic.oup.com
Abstract Short Linear Motifs (SLiMs) are the smallest structural and functional components of
modular eukaryotic proteins. They are also the most abundant, especially when considering …
modular eukaryotic proteins. They are also the most abundant, especially when considering …
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose serious threats to …
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose serious threats to …
Role of adaptin protein complexes in intracellular trafficking and their impact on diseases
Adaptin proteins (APs) play a crucial role in intracellular cell trafficking. The 'classical'role of
APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins …
APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins …
Viral interactions with adaptor-protein complexes: a ubiquitous trait among viral species
I Strazic Geljic, P Kucan Brlic, L Musak… - International journal of …, 2021 - mdpi.com
Numerous viruses hijack cellular protein trafficking pathways to mediate cell entry or to
rearrange membrane structures thereby promoting viral replication and antagonizing the …
rearrange membrane structures thereby promoting viral replication and antagonizing the …
The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection
The signaling pathways and cellular functions regulated by the four Numb-associated
kinases are largely unknown. We reported that AAK1 and GAK control intracellular trafficking …
kinases are largely unknown. We reported that AAK1 and GAK control intracellular trafficking …
Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects
Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for
pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a …
pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a …
Exosomes derived from umbilical cord mesenchymal stem cells ameliorate ischemic brain injury in mice by regulating AAK1 via miR-664a-5p
B Shen, N Liu, Y Dai - International Journal of Neuroscience, 2024 - Taylor & Francis
Objective To identify the molecular targets of MSC-derived exosomes in treating cerebral
ischemia and elucidate their therapeutic mechanisms. Methods We utilized a mouse model …
ischemia and elucidate their therapeutic mechanisms. Methods We utilized a mouse model …
Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents
B Martinez-Gualda, M Graus, A Camps… - Frontiers in …, 2022 - frontiersin.org
RNA viral infections, including those caused by respiratory syncytial virus (RSV), severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Venezuelan Equine …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Venezuelan Equine …