[HTML][HTML] Recent preclinical and clinical progress in liposomal doxorubicin

K Aloss, P Hamar - Pharmaceutics, 2023 - mdpi.com
Doxorubicin (DOX) is a potent anti-cancer agent that has garnered great interest in research
due to its high efficacy despite dose-limiting toxicities. Several strategies have been …

Forcing the antitumor effects of HSPs using a modulated electric field

CA Minnaar, A Szasz - Cells, 2022 - mdpi.com
The role of Heat Shock Proteins (HSPs) is a “double-edged sword” with regards to tumors.
The location and interactions of HSPs determine their pro-or antitumor activity. The present …

Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model

PHL Viana, CA Schvarcz, LO Danics, B Besztercei… - Scientific Reports, 2024 - nature.com
Female breast cancer is the most diagnosed cancer worldwide. Triple negative breast
cancer (TNBC) is the most aggressive type and there is no existing endocrine or targeted …

[HTML][HTML] Targeting the heat shock response induced by modulated electro-hyperthermia (mEHT) in cancer

P Viana, P Hamar - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Abstract The Heat Shock Response (HSR) is a cellular stress reaction crucial for cell survival
against stressors, including heat, in both healthy and cancer cells. Modulated electro …

Enhancing therapeutic efficacy in triple‐negative breast cancer and melanoma: synergistic effects of modulated electro‐hyperthermia (mEHT) with NSAIDs especially …

N Giunashvili, JM Thomas, CA Schvarcz… - Molecular …, 2024 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is a leading cause of cancer mortality and lacks
modern therapy options. Modulated electro‐hyperthermia (mEHT) is an adjuvant therapy …

External basic hyperthermia devices for preclinical studies in small animals

MI Priester, S Curto, GC van Rhoon, TLM Ten Hagen - Cancers, 2021 - mdpi.com
Simple Summary The application of mild hyperthermia can be beneficial for solid tumor
treatment by induction of sublethal effects on a tissue-and cellular level. When designing a …

Digoxin-Mediated Inhibition of Potential Hypoxia-Related Angiogenic Repair in Modulated Electro-Hyperthermia (mEHT)-Treated Murine Triple-Negative Breast …

SMZ Bokhari, K Aloss, PH Leroy Viana… - ACS Pharmacology & …, 2024 - ACS Publications
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer type with no
targeted therapy and hence limited treatment options. Modulated electrohyperthermia …

Modulated Electro-Hyperthermia Accelerates Tumor Delivery and Improves Anticancer Activity of Doxorubicin Encapsulated in Lyso-Thermosensitive Liposomes in …

K Aloss, SMZ Bokhari, PH Leroy Viana… - International Journal of …, 2024 - mdpi.com
Modulated electro-hyperthermia (mEHT) is an adjuvant cancer therapy that enables tumor-
selective heating (+ 2.5° C). In this study, we investigated whether mEHT accelerates the …

Heterogeneous heat absorption is complementary to radiotherapy

A Szasz - Cancers, 2022 - mdpi.com
Simple Summary This review shows the advantages of heterogeneous heating of selected
malignant cells in harmonic synergy with radiotherapy. The main clinical achievement of this …

A new role of acute phase proteins: Local production is an ancient, general stress-response system of mammalian cells

P Hamar - International Journal of Molecular Sciences, 2022 - mdpi.com
The prevailing general view of acute-phase proteins (APPs) is that they are produced by the
liver in response to the stress of the body as part of a systemic acute-phase response. We …