Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …

The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …

Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct
conversions between differentiated cell lineages represent powerful approaches to engineer …

Abstract Cardiac miRNAs (miR-1, miR133a, miR-208a/b, and miR-499) are abundantly
expressed in the myocardium. They play a central role in cardiogenesis, heart function and …

Background: Reprogramming of cardiac fibroblasts into induced cardiomyocyte-like cells in
situ represents a promising strategy for cardiac regeneration. A combination of 3 cardiac …

Rationale: Generation of induced cardiac myocytes (iCMs) directly from fibroblasts offers
great opportunities for cardiac disease modeling and cardiac regeneration. A major …

Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage
conversion, thereby reprogramming a somatic cell's identity. To determine the molecular …

Fibroblasts can be directly reprogrammed into cardiomyocyte-like cells (iCMs) by
overexpression of cardiac transcription factors, including Gata4, Mef2c, and Tbx5; however …

Direct cardiac reprogramming of fibroblasts to cardiomyocytes presents an attractive
therapeutic strategy to restore cardiac function following injury. Cardiac reprogramming was …

Conversion of fibroblasts into functional cardiomyocytes represents a potential means of
restoring cardiac function after myocardial infarction, but so far this process remains …