Stimuli-responsive therapeutic metallodrugs

X Wang, X Wang, S Jin, N Muhammad, Z Guo - Chemical reviews, 2018 - ACS Publications
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

J Akhtar, AA Khan, Z Ali, R Haider, MS Yar - European journal of medicinal …, 2017 - Elsevier
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Platinum-containing heterometallic complexes in cancer therapy: advances and perspectives

L Ma, L Li, G Zhu - Inorganic Chemistry Frontiers, 2022 - pubs.rsc.org
Platinum-based anticancer drugs are among the most widely used antineoplastics in clinical
settings. Their therapeutic applications and outcomes are, however, greatly hampered by …

Biological evaluation of new nickel (II) metallates: Synthesis, DNA/protein binding and mitochondrial mediated apoptosis in human lung cancer cells (A549) via ROS …

P Kalaivani, S Saranya, P Poornima… - European Journal of …, 2014 - Elsevier
A series of novel nickel (II) thiosemicarbazone complexes (1–4) have been prepared and
characterized by various spectral, analytical techniques and X-ray crystallography. Further …

Halogens effect on spectroscopy, anticancer and molecular docking studies for platinum complexes

HH Khalid, S Erkan, N Bulut - Optik, 2021 - Elsevier
Abstract Pt (dpb) Cl, Pt (Fdpb) Cl, Pt (F 2 dpb) Cl and Pt (dpb) I complexes are examined by
computational chemistry method in all aspects. Hartree-Fock (HF) and Density Functional …

Anticancer platinum agents and light

J Gurruchaga-Pereda, A Martinez, A Terenzi… - Inorganica Chimica …, 2019 - Elsevier
Since the discovery of cisplatin, light activation has been employed as a strategy to switch
and improve the anticancer effects of platinum compounds. This contribution highlights …

Platinum complexes as light promoted anticancer agents: a redefined strategy for controlled activation

K Mitra - Dalton Transactions, 2016 - pubs.rsc.org
Site-specific delivery and amenable activation of prodrugs are indispensible criteria for
designing novel anticancer agents. Platinum based drugs vanguard the chemotherapeutic …

New mixed ligand palladium (II) complexes based on the antiepileptic drug sodium valproate and bioactive nitrogen-donor ligands: Synthesis, structural …

L Tabrizi, H Chiniforoshan, H Tavakol - Spectrochimica Acta Part A …, 2015 - Elsevier
Abstract The complexes [Pd (valp) 2 (imidazole) 2](1),[Pd (valp) 2 (pyrazine) 2](2)(valp is
sodium valproate) have been synthesized and characterized using IR, 1 H NMR, 13 C {1 H} …

2-(Phenylazo) pyridineplatinum (II) catecholates showing photocytotoxicity, nuclear uptake, and glutathione-triggered ligand release

K Mitra, S Patil, P Kondaiah… - Inorganic Chemistry, 2015 - ACS Publications
Platinum (II) complexes [Pt (pap)(an-cat)](1) and [Pt (pap)(py-cat)](2) with 2-(phenylazo)
pyridine (pap), 4-[2-[(anthracen-9-ylmethylene) amino] ethyl] benzene-1, 2-diol (H2an-cat) …

Synthesis, characterization, structural analysis and DNA binding studies of nickel (II)–triphenylphosphine complex of ONS donor ligand–Multisubstituted …

SM Kumar, K Dhahagani, J Rajesh, K Nehru, J Annaraj… - Polyhedron, 2013 - Elsevier
A new kind of Ni (II) complex of the type,[Ni (PPh3)(L)](1),{where L= chemosensor
thiosemicarbazone= 2-(3-bromo-5-chloro-2-hydroxybenzylidene)-N-phenyhydrazine …