1. This paper reviews recent findings on cellular and humoral immunity and inflammatory
markers in depression. 2. 2. It is shown that major depression may be accompanied by …

There is now some evidence that major depression may be accompanied by an immune
response. The latter condition is suggested by elevated secretion of neopterin and interferon …

A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

A revision of the 2000 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken to …

• Although the major classes of antidepressant drugs have been available for over 30 years,
clinicians are still unable to predict accurately the response of their depressed patients to …

Despite much research, the pathophysiology underlying lower L-tryptophan (L-TRP)
availability in major depression has remained elusive. The present study investigates …

Background Recent US and UK clinical practice guidelines recommend that second‐
generation antidepressants should be considered amongst the best first‐line options when …

It has been proposed that focusing on brain serotonin synthesis can advance antidepressant
drug development. Biochemical aspects of the serotonin deficiency in major depressive …

Premenstrual dysphoric disorder (PMDD) is characterized by a range of physical and
affective symptoms including anxiety, irritability, anhedonia, social withdrawal and …

Serum total tryptophan and the five competing amino acids (CAA), ie, valine, leucine,
tyrosine, phenylalanine, and isoleucine were determined in 35 major depressed subjects of …