Hyperpolarized 129Xe MRI Abnormalities in Dyspneic Patients 3 Months after COVID-19 Pneumonia: Preliminary Results

JT Grist, M Chen, GJ Collier, B Raman, G Abueid… - Radiology, 2021 - pubs.rsna.org
Background SARS-CoV-2 targets angiotensin-converting enzyme 2–expressing cells in the
respiratory tract. There are reports of breathlessness in patients many months after infection …

Current methods for hyperpolarized [1‐13C]pyruvate MRI human studies

PEZ Larson, JML Bernard, JA Bankson… - Magnetic resonance …, 2024 - Wiley Online Library
Abstract MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can
measure processes such as localized metabolism that is altered in numerous cancers, liver …

Hyperpolarized metabolic mri—acquisition, reconstruction, and analysis methods

PEZ Larson, JW Gordon - Metabolites, 2021 - mdpi.com
Hyperpolarized metabolic MRI with 13 C-labeled agents has emerged as a powerful
technique for in vivo assessments of real-time metabolism that can be used across scales of …

Whole‐Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1‐13C]pyruvate MRI

PM Lee, HY Chen, JW Gordon, ZJ Wang… - Journal of Magnetic …, 2022 - Wiley Online Library
Background Hyperpolarized 13C MRI quantitatively measures enzyme‐catalyzed
metabolism in cancer and metabolic diseases. Whole‐abdomen imaging will permit …

Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-13C]pyruvate cardiovascular magnetic …

SH Joergensen, ESS Hansen, N Bøgh… - Journal of …, 2022 - Springer
Abstract Background Hyperpolarized (HP)[1-13C] pyruvate cardiovascular magnetic
resonance (CMR) imaging can visualize the uptake and intracellular conversion of [1-13C] …

Hyperpolarized 13C Metabolic MRI of Patients with Pancreatic Ductal Adenocarcinoma

JW Gordon, HY Chen, T Nickles, PM Lee… - Journal of Magnetic …, 2024 - Wiley Online Library
Background Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer‐
related death in the United States. However, early response assessment using the current …

Initial Experience on Hyperpolarized [1-13C]Pyruvate MRI Multicenter Reproducibility—Are Multicenter Trials Feasible?

N Bøgh, JW Gordon, ESS Hansen, RA Bok, JU Blicher… - Tomography, 2022 - mdpi.com
Background: Magnetic resonance imaging (MRI) with hyperpolarized [1-13C] pyruvate
allows real-time and pathway specific clinical detection of otherwise unimageable in vivo …

Lactate saturation limits bicarbonate detection in hyperpolarized 13C‐pyruvate MRI of the brain

N Bøgh, JT Grist, CW Rasmussen… - Magnetic …, 2022 - Wiley Online Library
Purpose To investigate the potential effects of [1‐13C] lactate RF saturation pulses on [13C]
bicarbonate detection in hyperpolarized [1‐13C] pyruvate MRI of the brain. Methods …

Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2‐13C]pyruvate MRS

HY Chen, JW Gordon, N Dwork, BT Chung… - NMR in …, 2024 - Wiley Online Library
Introduction The healthy heart has remarkable metabolic flexibility that permits rapid
switching between mitochondrial glucose oxidation and fatty acid oxidation to generate ATP …

RF coil design for accurate parallel imaging on 13C MRSI using 23Na sensitivity profiles

JD Sanchez‐Heredia, RB Olin, JT Grist… - Magnetic resonance …, 2022 - Wiley Online Library
Purpose To develop a coil‐based method to obtain accurate sensitivity profiles in 13C MRI
at 3T from the endogenous 23Na. An eight‐channel array is designed for 13C MR …