Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures

V Crunelli, ML Lőrincz, C McCafferty, RC Lambert… - Brain, 2020 - academic.oup.com
Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …

Genetic generalized epilepsies in adults—challenging assumptions and dogmas

BJ Vorderwülbecke, B Wandschneider… - Nature Reviews …, 2022 - nature.com
Genetic generalized epilepsy (GGE) syndromes start during childhood or adolescence, and
four commonly persist into adulthood, making up 15–20% of all cases of epilepsy in adults …

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy

TA Glauser, A Cnaan, S Shinnar, DG Hirtz… - … England Journal of …, 2010 - Mass Medical Soc
Background Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is
usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and …

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months

TA Glauser, A Cnaan, S Shinnar, DG Hirtz… - …, 2013 - Wiley Online Library
Purpose: Determine the optimal initial monotherapy for children with newly diagnosed
childhood absence epilepsy (CAE) based on 12 months of double‐blind therapy. Methods …

Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities

R Caplan, P Siddarth, L Stahl, E Lanphier, P Vona… - …, 2008 - Wiley Online Library
Purpose: Evidence for a poor psychiatric, social, and vocational adult outcome in childhood
absence epilepsy (CAE) suggests long‐term unmet mental health, social, and vocational …

Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy

D Masur, S Shinnar, A Cnaan, RC Shinnar, P Clark… - Neurology, 2013 - AAN Enterprises
Objective: To determine the neurocognitive deficits associated with newly diagnosed
untreated childhood absence epilepsy (CAE), develop a model describing the factorial …

Altered functional connectivity in default mode network in absence epilepsy: a resting‐state fMRI study

C Luo, Q Li, Y Lai, Y Xia, Y Qin, W Liao… - Human brain …, 2011 - Wiley Online Library
Dysfunctional default mode network (DMN) has been observed in various mental disorders,
including epilepsy (see review Broyd et al.[2009]: Neurosci Biobehav Rev 33: 279–296) …

Memory function in childhood epilepsy syndromes

MA Nolan, MA Redoblado, S Lah… - … of paediatrics and …, 2004 - Wiley Online Library
Objective: Children with epilepsy are at risk of specific cognitive deficits. We aimed to
compare and characterize the memory function of children with childhood absence epilepsy …

Early treatment suppresses the development of spike‐wave epilepsy in a rat model

H Blumenfeld, JP Klein, U Schridde, M Vestal… - …, 2008 - Wiley Online Library
Purpose: Current treatments for epilepsy may control seizures, but have no known effects on
the underlying disease. We sought to determine whether early treatment in a model of …

Cognitive function in idiopathic generalized epilepsy of childhood

Y Henkin, M Sadeh, S Kivity, E Shabtai… - … medicine and child …, 2005 - cambridge.org
This study evaluated the cognitive profiles of children with idiopathic generalized epilepsy
(IGE), uniformly treated with valproic acid with well-controlled seizures. Twenty-four were …