An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

[HTML][HTML] Pathogen diversity, immunity, and the fate of infections: lessons learned from Trypanosoma cruzi human–host interactions

LMD Magalhães, KJ Gollob, B Zingales… - The Lancet …, 2022 - thelancet.com
The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

[HTML][HTML] Recent advances on the piezoelectric, electrochemical, and optical biosensors for the detection of protozoan pathogens

M Feyziazar, M Amini, A Jahanban-Esfahlan… - TrAC Trends in …, 2022 - Elsevier
The important protozoan parasites including Plasmodium, Leishmania, Toxoplasma,
Trypanosoma and Giardia have been proved as the main reason initiating and developing …

[HTML][HTML] A Review on the Immunological Response against Trypanosoma cruzi

G Macaluso, F Grippi, S Di Bella, V Blanda, F Gucciardi… - Pathogens, 2023 - mdpi.com
Chagas disease is a chronic systemic infection transmitted by Trypanosoma cruzi. Its life
cycle consists of different stages in vector insects and host mammals. Trypanosoma cruzi …

Harnessing RNA technology to advance therapeutic vaccine antigens against chagas disease

C Mancino, J Pollet, A Zinger, KM Jones… - … Applied Materials & …, 2024 - ACS Publications
Chagas disease (CD)(American trypanosomiasis caused by Trypanosoma cruzi) is a
parasitic disease endemic in 21 countries in South America, with increasing global spread …

[HTML][HTML] Vaccines against emerging and neglected infectious diseases: An overview

L Vuitika, WA Prates-Syed, JDQ Silva, KP Crema… - Vaccines, 2022 - mdpi.com
Neglected Tropical Diseases (NTDs) are a group of diseases that are highly prevalent in
tropical and subtropical regions, and closely associated with poverty and marginalized …

Potential role of antioxidants as adjunctive therapy in Chagas disease

JP Sánchez-Villamil, PK Bautista-Niño… - Oxidative Medicine …, 2020 - Wiley Online Library
Chagas disease (CD) is one of the most important neglected tropical diseases in the
American continent. Host‐derived nitroxidative stress in response to Trypanosoma cruzi …

Preclinical advances and the immunophysiology of a new therapeutic Chagas disease vaccine

KM Jones, C Poveda, L Versteeg… - Expert review of …, 2022 - Taylor & Francis
Introduction Chronic infection with the protozoal parasite Trypanosoma cruzi leads to a
progressive cardiac disease, known as chronic Chagasic cardiomyopathy (CCC). A new …

[HTML][HTML] Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease

KM Jones, EN Mangin, CL Reynolds… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Chagas disease, caused by chronic infection with the protozoan parasite
Trypanosoma cruzi, affects 6-7 million people worldwide. The major clinical manifestation of …

Veterinary Chagas Disease (American Trypanosomiasis) in the United States

SA Hamer, AB Saunders - Veterinary Clinics: Small Animal …, 2022 - vetsmall.theclinics.com
Trypanosoma cruzi is a zoonotic, protozoan parasite that causes Chagas disease in
mammals. The parasite was first described by the Brazilian physician Dr Carlos Chagas in …