bHLH–PAS proteins in cancer
Mammalian basic HLH (helix–loop–helix)–PER–ARNT–SIM (bHLH–PAS) proteins are
heterodimeric transcription factors that sense and respond to environmental signals (such as …
heterodimeric transcription factors that sense and respond to environmental signals (such as …
Diversity in Genetic In Vivo Methods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System
B Stynen, H Tournu, J Tavernier… - … and molecular biology …, 2012 - Am Soc Microbiol
The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …
Structural basis for aryl hydrocarbon receptor-mediated gene activation
The aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT) constitute a
heterodimeric basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain containing …
heterodimeric basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain containing …
Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex
The aryl hydrocarbon receptor (AHR) belongs to the PAS (PER-ARNT-SIM) family
transcription factors and mediates broad responses to numerous environmental pollutants …
transcription factors and mediates broad responses to numerous environmental pollutants …
NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior
The suprachiasmatic nucleus (SCN) is the master circadian pacemaker in mammals and is
entrained by environmental light. However, the molecular basis of the response of the SCN …
entrained by environmental light. However, the molecular basis of the response of the SCN …
Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to
xenobiotics and responds by regulating the expression of gene programs required for …
xenobiotics and responds by regulating the expression of gene programs required for …
The AhR signaling mechanism: A structural point of view
Abstract The Aryl hydrocarbon Receptor (AhR) is a well-known sensor of xenobiotics;
moreover, it is considered a promising drug target as it is involved in the regulation of many …
moreover, it is considered a promising drug target as it is involved in the regulation of many …
Benzo (α) pyrene induces oxidative stress and inflammation in human vascular endothelial cells through AhR and NF-κB pathways
H Shi, J Liu, H Gao - Microvascular Research, 2021 - Elsevier
Exposure to polycyclic aromatic hydrocarbons (PAHs) contributes to development and
exacerbation of atherosclerosis and cardiovascular disease. However, the underlying …
exacerbation of atherosclerosis and cardiovascular disease. However, the underlying …
Recent advances in the development of AHR antagonists in immuno-oncology
L Sun - RSC Medicinal Chemistry, 2021 - pubs.rsc.org
The arylhydrocarbon receptor (AHR) is a ligand activated transcription factor that controls
the expression of a number of immunosuppressive signaling molecules, including the …
the expression of a number of immunosuppressive signaling molecules, including the …
A network model for angiogenesis in ovarian cancer
Background We recently identified two robust ovarian cancer subtypes, defined by the
expression of genes involved in angiogenesis, with significant differences in clinical …
expression of genes involved in angiogenesis, with significant differences in clinical …