Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence,
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …

Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

Background Despite integrin being highlighted as a stiffness‐sensor molecule in matrix
stiffness‐driven angiogenesis, other stiffness‐sensor molecules and their mechanosensory …

Hypoxia-inducible factor-1α (HIF-1α) is widely distributed in human cells, and it can form
different signaling pathways with various upstream and downstream proteins, mediate …

Conventional treatment fails to completely eliminate highly invasive breast cancer cells, and
most surviving breast cancer cells tend to reproliferate and metastasize by forming …

Physiologically, teeth and periodontal tissues are exposed to occlusal forces throughout
their lifetime. Following occlusal unloading, unbalanced bone remodeling manifests as a net …

The remodeling of specific calcium-permeable ion channels is a feature of some breast
cancer subtypes. ORAI1 is a protein that forms a calcium-permeable ion channel …

Calcium signaling, in addition to its numerous physiological roles, is also implicated in
several pathological conditions including cancer. An increasing body of evidence suggest …

Highlights•Drug resistance of cancer cells, which results in treatment failure, is a major
concern in medical oncology.•Ca 2+ plays an important role in acquired drug resistance by …

Hypoxia, the decline of tissue oxygen stress, plays a role in mediating cellular processes.
Cardiovascular disease, relatively widespread with increased mortality, is closely correlated …