In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Simple Summary Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …

Objective Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and
includes tumours that are among the most treatment resistant and with worst outcomes. This …

Serrated lesions are histologically heterogeneous, and detection can be challenging as
these lesions have subtle features that may be missed by endoscopy. Furthermore, while …

Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC
has progressed from initial discoveries which focused on the stepwise accumulation of key …

In the March 1 issue of Cancer Research, we identified the Wnt receptor Fzd7 as an
attractive therapeutic target for the treatment of gastric cancer. In summary, we showed that …

Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway.
The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and …

Colorectal cancer (CRC) is one of the most common causes of cancer morbidity in both
sexes but shows sex differences. First, sex-specific differences in tumor recurrence and …

Studies of colorectal cancer (CRC) originating through the conventional adenoma-
carcinoma sequence have provided insight into the molecular mechanisms controlling its …