HIV and antiretroviral therapy-related fat alterations
Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …
HIV-associated cardiovascular disease pathogenesis: an emerging understanding through imaging and immunology
Cardiac abnormalities were identified early in the epidemic of AIDS, predating the isolation
and characterization of the etiologic agent, HIV. Several decades later, the causation and …
and characterization of the etiologic agent, HIV. Several decades later, the causation and …
SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics
SARS-CoV-2 is a newly identified coronavirus that causes the respiratory disease called
coronavirus disease 2019 (COVID-19). With an urgent need for therapeutics, we lack a full …
coronavirus disease 2019 (COVID-19). With an urgent need for therapeutics, we lack a full …
Catheter ablation approach and outcome in HIV+ patients with recurrent atrial fibrillation
VM La Fazia, N Pierucci, S Mohanty… - Journal of …, 2023 - Wiley Online Library
Introduction Earlier studies have shown a clear association between severity of human
immunodeficiency virus (HIV) infection and incident atrial fibrillation (AF). We present the …
immunodeficiency virus (HIV) infection and incident atrial fibrillation (AF). We present the …
Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments
HIV infection and antiretroviral therapy alter mitochondrial function, which can progressively
lead to mitochondrial damage and accelerated aging. The interaction between persistent …
lead to mitochondrial damage and accelerated aging. The interaction between persistent …
Autophagy-enhancing drugs limit mucosal HIV-1 acquisition and suppress viral replication ex vivo
APM Cloherty, NH van Teijlingen, TJTHD Eisden… - Scientific reports, 2021 - nature.com
Current direct-acting antiviral therapies are highly effective in suppressing HIV-1 replication.
However, mucosal inflammation undermines prophylactic treatment efficacy, and HIV-1 …
However, mucosal inflammation undermines prophylactic treatment efficacy, and HIV-1 …
Extracellular vesicles from HTLV-1 infected cells modulate target cells and viral spread
DO Pinto, S Al Sharif, G Mensah, M Cowen, P Khatkar… - Retrovirology, 2021 - Springer
Abstract Background The Human T-cell Lymphotropic Virus Type-1 (HTLV-1) is a blood-
borne pathogen and etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV …
borne pathogen and etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV …
Cardiac arrhythmias in viral infections
Background The current COVID-19 pandemic has led to many studies examining its
arrhythmogenic effects. However, there are many other viruses that are capable of inducing …
arrhythmogenic effects. However, there are many other viruses that are capable of inducing …
Complexities of JC polyomavirus receptor-dependent and-independent mechanisms of infection
J Morris-Love, WJ Atwood - Viruses, 2022 - mdpi.com
JC polyomavirus (JCPyV) is a small non-enveloped virus that establishes lifelong, persistent
infection in most of the adult population. Immune-competent patients are generally …
infection in most of the adult population. Immune-competent patients are generally …
HIV Nef and antiretroviral therapy have an inhibitory effect on autophagy in human astrocytes that may contribute to HIV-associated neurocognitive disorders
L Cheney, H Guzik, FP Macaluso, F Macian… - Cells, 2020 - mdpi.com
A significant number of people living with HIV (PLWH) develop HIV-associated
neurocognitive disorders (HAND) despite highly effective antiretroviral therapy (ART) …
neurocognitive disorders (HAND) despite highly effective antiretroviral therapy (ART) …