Membrane-enveloped viruses are a leading cause of viral epidemics, and there is an
outstanding need to develop broad-spectrum antiviral strategies to treat and prevent …

Background Dengue is the most prevalent and rapidly spreading mosquito-borne viral
disease. We present the global, regional and national burden of dengue from 1990 to 2019 …

Background: Dengue has become one of the major vector-borne diseases, which has been
an important public health concern. We aimed to estimate the disease burden of dengue in …

Abstract Background Vector-borne diseases (VBDs) continue to represent a global threat,
with “old” diseases like malaria, and “emergent” or “re-emergent” ones like Zika, because of …

Abstract Dengue virus type 2 (DENV-2) contributes substantially to the dengue burden and
dengue-related mortality in the tropics and sub-tropics. DENV-2 includes six genotypes …

Summary Background An outbreak of Zika virus infection was detected in Singapore in
August, 2016. We report the first comprehensive analysis of a national response to an …

This paper summarises the lessons learnt in dengue epidemiology, risk factors, and
prevention in Singapore over the last half a century, during which Singapore evolved from a …

Urbanization drives the epidemiology of infectious diseases to many threats and new
challenges. In this research, we study the interplay between human mobility and dengue …

Background Singapore experiences endemic dengue, with 2013 being the largest outbreak
year known to date, culminating in 22,170 cases. Given the limited resources available, and …

Singapore has experienced periodic dengue epidemics despite maintaining a low Aedes
house index. Each epidemic was associated with a switch in the predominant serotype. We …