The cell biology of synapse formation

TC Südhof - Journal of Cell Biology, 2021 - rupress.org
In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …

Towards an understanding of synapse formation

TC Südhof - Neuron, 2018 - cell.com
Synapses are intercellular junctions specialized for fast, point-to-point information transfer
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …

Synaptic neurexin complexes: a molecular code for the logic of neural circuits

TC Südhof - Cell, 2017 - cell.com
Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

Alternative splicing of latrophilin-3 controls synapse formation

S Wang, C DeLeon, W Sun, SR Quake, BL Roth… - Nature, 2024 - nature.com
The assembly and specification of synapses in the brain is incompletely understood,–.
Latrophilin-3 (encoded by Adgrl3, also known as Lphn3)—a postsynaptic adhesion G …

Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins

R Sando, X Jiang, TC Südhof - Science, 2019 - science.org
INTRODUCTION In the brain, synaptic connections form neuronal communication networks,
thereby constructing neural circuits. Synaptic connections are exquisitely specific and …

Alternative splicing of presynaptic neurexins differentially controls postsynaptic NMDA and AMPA receptor responses

J Dai, J Aoto, TC Südhof - Neuron, 2019 - cell.com
AMPA-and NMDA-type glutamate receptors mediate distinct postsynaptic signals that differ
characteristically among synapses. How postsynaptic AMPA-and NMDA-receptor levels are …

Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology

T Lala, RA Hall - Physiological Reviews, 2022 - journals.physiology.org
Adhesion G protein-coupled receptors: structure, signaling, physiology, and
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …

Structural basis for teneurin function in circuit-wiring: a toxin motif at the synapse

J Li, M Shalev-Benami, R Sando, X Jiang, A Kibrom… - Cell, 2018 - cell.com
Teneurins (TENs) are cell-surface adhesion proteins with critical roles in tissue development
and axon guidance. Here, we report the 3.1-Å cryoelectron microscopy structure of the …

Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands

X Zhang, PY Lin, K Liakath-Ali, TC Südhof - Nature Communications, 2022 - nature.com
Extensive studies concluded that homophilic interactions between pre-and postsynaptic
teneurins, evolutionarily conserved cell-adhesion molecules, encode the specificity of …

Latrophilin GPCR signaling mediates synapse formation

R Sando, TC Südhof - Elife, 2021 - elifesciences.org
Neural circuit assembly in the brain requires precise establishment of synaptic connections,
but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are …