Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-
mutation-driven clonal evolution and subsequent transformation is a crucial step toward the …

The bone marrow supports and regulates hematopoiesis, responding to physiological
requirements for blood cell production over ontogeny and during pathological challenges …

A lack of models that recapitulate the complexity of human bone marrow has hampered
mechanistic studies of normal and malignant hematopoiesis and the validation of novel …

X-linked chronic granulomatous disease (CGD) is associated with defective phagocytosis,
life-threatening infections, and inflammatory complications. We performed a clinical trial of …

Alternative splicing is an important source of heterogeneity underlying gene expression
between individual cells but remains an understudied area due to the paucity of …

Hematopoietic stem and progenitor cells (HSPCs) give rise to the blood system and
maintain hematopoiesis throughout the human lifespan. Here, we report a transcriptional …

Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations,
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …

CD19-directed immunotherapies have revolutionized the treatment of advanced B-cell acute
lymphoblastic leukemia (B-ALL). Despite initial impressive rates of complete remission (CR) …

Erythroblastic islands (EBIs) are the specialized structures for erythropoiesis, but they have
never been found functional in tumors. As the most common pediatric liver malignancy …