In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Aliphatic three-and four-membered rings including cyclopropanes, cyclobutanes, oxetanes,
azetidines and bicyclo [1.1. 1] pentanes have been increasingly exploited in medicinal …

Three-and four-membered rings, widespread motifs in nature and medicinal chemistry, have
fascinated chemists ever since their discovery. However, due to energetic considerations …

Conspectus The implementation of any chemical reaction in a structurally complex setting
(King, SMJ Org. Chem. 2014, 79, 8937) confronts structurally defined barriers: steric …

Fluorinated fused rings are challenging to construct from simple starting materials. Herein,
we report the first photocatalyzed cascade reactions of readily available cyclopropanols and …

A bifunctional iminophosphorane (BIMP)-catalyzed, enantioselective intramolecular oxa-
Michael reaction of alcohols to tethered, low electrophilicity Michael acceptors is described …

The synthesis of four membered heterocycles usually requires multi‐step procedures and
prefunctionalized reactants. A straightforward alternative is the photochemical [2+ 2] …

Cyclobutanes are increasingly used in medicinal chemistry in the search for relevant
biological properties. Important characteristics of the cyclobutane ring include its unique …

Visible light and photoredox catalysis have emerged as a powerful and long-lasting tool for
organic synthesis, demonstrating the importance of a variety of chemical bond formation …