Sexually transmitted infections and HIV in the era of antiretroviral treatment and prevention: the biologic basis for epidemiologic synergy

MS Cohen, OD Council, JS Chen - Journal of the International …, 2019 - Wiley Online Library
Introduction HIV is a unique sexually transmitted infection (STI) that is greatly affected by
other concomitant “classical” bacterial and viral STI s that cause genital ulcers and/or …

Prevalence of sexually transmitted co-infections in people living with HIV/AIDS: systematic review with implications for using HIV treatments for prevention

SC Kalichman, J Pellowski, C Turner - Sexually transmitted infections, 2011 - sti.bmj.com
Sexually transmitted co-infections increase HIV infectiousness through local inflammatory
processes. The prevalence of STI among people living with HIV/AIDS has implications for …

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

A Sigal, JT Kim, AB Balazs, E Dekel, A Mayo, R Milo… - Nature, 2011 - nature.com
Latency and ongoing replication have both been proposed to explain the drug-insensitive
human immunodeficiency virus (HIV) reservoir maintained during antiretroviral therapy …

HPTN 071 (PopART): rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal …

R Hayes, H Ayles, N Beyers, K Sabapathy, S Floyd… - Trials, 2014 - Springer
Background Effective interventions to reduce HIV incidence in sub-Saharan Africa are
urgently needed. Mathematical modelling and the HIV Prevention Trials Network (HPTN) …

Significance and clinical management of persistent low-level viremia and very-low-level viremia in HIV-1-infected patients

P Ryscavage, S Kelly, JZ Li, PR Harrigan… - Antimicrobial agents …, 2014 - Am Soc Microbiol
ABSTRACT A goal of HIV therapy is to sustain suppression of the plasma viral load below
the detection limits of clinical assays. However, widely followed treatment guidelines diverge …

[HTML][HTML] Exosomes in human semen restrict HIV-1 transmission by vaginal cells and block intravaginal replication of LP-BM5 murine AIDS virus complex

MN Madison, PH Jones, CM Okeoma - Virology, 2015 - Elsevier
Exosomes are membranous extracellular nanovesicles secreted by diverse cell types.
Exosomes from healthy human semen have been shown to inhibit HIV-1 replication and to …

[PDF][PDF] British HIV Association guidelines for the management of HIV in pregnancy and postpartum 2018

Y Gilleece, S Tariq, A Bamford, S Bhagani… - HIV …, 2019 - discovery.ucl.ac.uk
A key goal of managing HIV in pregnancy and postpartum is to optimise a woman's own
health. Furthermore, one of the major successes in the management of individuals living …

Compartmentalization, viral evolution, and viral latency of HIV in the CNS

MM Bednar, CB Sturdevant, LA Tompkins… - Current HIV/AIDS …, 2015 - Springer
Human immunodeficiency virus type 1 (HIV-1) infection occurs throughout the body and can
have dramatic physical effects, such as neurocognitive impairment in the central nervous …

Measuring the latent reservoir in vivo

M Massanella, DD Richman - The Journal of clinical …, 2016 - Am Soc Clin Investig
Current efforts toward achieving a cure for HIV are focused on developing strategies to
eliminate latently infected CD4+ T cells, which represent the major barrier to virus …

Persistent Borrelia infection in patients with ongoing symptoms of Lyme disease

MJ Middelveen, E Sapi, J Burke, KR Filush, A Franco… - Healthcare, 2018 - mdpi.com
Introduction: Lyme disease is a tickborne illness that generates controversy among medical
providers and researchers. One of the key topics of debate is the existence of persistent …