Nitric oxide and peroxynitrite in health and disease

P Pacher, JS Beckman, L Liaudet - Physiological reviews, 2007 - journals.physiology.org
The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

The L-arginine-nitric oxide pathway

S Moncada, A Higgs - New England journal of medicine, 1993 - Mass Medical Soc
The discovery that mammalian cells generate nitric oxide, a gas previously considered to be
merely an atmospheric pollutant, is providing important information about many biologic …

Nociception from skeletal muscle in relation to clinical muscle pain

S Mense - Pain, 1993 - journals.lww.com
1. Introduction......................................... II. Anatomy and physiology................................ A. The
peripheral apparatus............................. Fiber composition of muscle nerves …

Nitric oxide: a key mediator in the early and late phase of carrageenan‐induced rat paw inflammation

D Salvemini, ZQ Wang, PS Wyatt… - British journal of …, 1996 - Wiley Online Library
1 The role of nitric oxide (NO) derived from constitutive and inducible nitric oxide synthase
(cNOS and iNOS) and its relationship to oxygen‐derived free radicals and prostaglandins …

Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure–activity relationships

HK Kim, BS Cheon, YH Kim, SY Kim, HP Kim - Biochemical pharmacology, 1999 - Elsevier
Flavonoids affect the inflammatory process of the mammalian system and possess anti-
inflammatory as well as immunomodulatory activities in vitro and in vivo. Since nitric oxide …

Nitric oxide (NO) and nociceptive processing in the spinal cord

ST Meller, GF Gebhart - Pain, 1993 - Elsevier
There is considerable evidence to implicate N-methyl-d-aspartate (NMDA) receptor
activation in the mechanisms that underly thermal hyperalgesia in the spinal cord. As many …

In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

M Bucci, JP Gratton, RD Rudic, L Acevedo… - Nature medicine, 2000 - nature.com
Caveolin-1, the primary coat protein of caveolae, has been implicated as a regulator of
signal transduction through binding of its “scaffolding domain” to key signaling molecules …

Inhibition of nitric oxide synthase as a potential therapeutic target

AJ Hobbs, A Higgs, S Moncada - Annual review of …, 1999 - annualreviews.org
▪ Abstract Nitric oxide (NO) regulates numerous physiological processes, including
neurotransmission, smooth muscle contractility, platelet reactivity, and the cytotoxic activity of …

Anti-inflammatory activity of macrolide antibiotics

A Ianaro, A Ialenti, P Maffia, L Sautebin… - … of Pharmacology and …, 2000 - ASPET
The effect of four macrolide antibiotics (roxithromycin, clarithromycin, erythromycin, and
azithromycin) on the generation of some mediators and cytokines involved in the …

Regulatory role of nitric oxide in cutaneous inflammation

MQ Man, JS Wakefield, TM Mauro, PM Elias - Inflammation, 2022 - Springer
Nitric oxide (NO), a signaling molecule, regulates biological functions in multiple
organs/tissues, including the epidermis, where it impacts permeability barrier homeostasis …