The desire to improve and decentralize diagnostic platforms to facilitate highly precise and
personalized medicine has motivated the development of a large number of electrochemical …

The ultimate goal of implantable bioanalytical sensors is to enable the continuous and
precise monitoring of clinically and physiologically important targets in the body for …

Dopamine (DA) midbrain neurons project to several striatal and cortical target areas and are
essentially involved in a puzzling variety of important brain functions such as action …

In the primary motor cortex (M1), layer 5 projection neurons signal directly to distant motor
structures to drive movement. Despite their pivotal position and acknowledged diversity …

Firing rate is an important means of encoding information in the nervous system. To reliably
encode a wide range of signals, neurons need to achieve a broad range of firing …

Little is known about the voltage-dependent potassium currents underlying spike
repolarization in midbrain dopaminergic neurons. Studying mouse substantia nigra pars …

Midbrain dopamine (DA) neurons play a central role in a wide range of behaviors, from
attention and motivation to motor control and reinforcement. The release of DA is modulated …

Midbrain dopamine (DA) neurons are slow pacemakers that maintain extracellular DA
levels. During the interspike intervals, subthreshold slow depolarization underlies …

The major endocannabinoid in the mammalian brain is the bioactive lipid 2-
arachidonoylglycerol (2-AG). The best-known effects of 2-AG are mediated by G-protein …

Twelve-to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed
progressive neuronal death of substantia nigra pars compacta (SNpc) dopaminergic cells. In …