Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a recently defined entity
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …

Mitochondrial DNA (mtDNA) variation in common diseases has been underexplored, partly
due to a lack of genotype calling and quality-control procedures. Developing an at-scale …

Chronic kidney disease (CKD) is a major global health problem with an increasing
prevalence partly driven by aging population structure. Both genomic and environmental …

Kidneys have a high energy demand to facilitate the reabsorption of the glomerular filtrate.
For this reason, renal cells have a high density of mitochondria. Mitochondrial cytopathies …

The kidney is a mitochondria-rich organ, and kidney diseases are recognized as
mitochondria-related pathologies. Intact mitochondrial DNA (mtDNA) maintains normal …

Background Gitelman syndrome is the most frequent hereditary salt-losing tubulopathy
characterized by hypokalemic alkalosis and hypomagnesemia. Gitelman syndrome is …

Mitochondrial cytopathies include a heterogeneous group of diseases that are characterized
by impaired oxidative phosphorylation, leading to multi organ involvement and progressive …

Background: Diabetic nephropathy (DN) is an important diabetic microvascular
complication, and it is becoming the leading cause of end-stage renal disease worldwide …