Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Tubulointerstitial inflammation is a common characteristic of acute and chronic kidney injury.
However, the mechanism by which the initial injury of tubular epithelial cells (TECs) drives …

Females typically develop higher antibody responses and experience more adverse
reactions following vaccination than males. These differences are observed in response to …

A properly mounted immune response is indispensable for recognizing and eliminating
danger arising from foreign invaders and tissue trauma. However, the'inflammatory …

Objectives We used a screening strategy of global serum microRNA (miRNA) profiling,
followed by a second stage of independent replication and exploration of liver expression of …

The paternal heredity of obesity and diabetes induced by a high-fat and/or high-sugar diet
(Western-like diet) has been demonstrated through epidemiological analysis of human …

Although known for many years as a nuclear factor (NF)-κB inhibitory and antiapoptotic
signaling protein, A20 has recently attracted much attention because of its ubiquitin …

A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts
multiple intracellular signalling cascades. Recent studies in three general areas have …

A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …