Metformin is a widely used biguanide drug due to its safety and low cost. It has been used
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …

The global prevalence of obesity is increasing rapidly with an exponential rise in incidence
of type 2 diabetes mellitus in recent years.'Diabesity', the term coined to show the strong …

Background Metformin might reduce insulin requirement and improve glycaemia in patients
with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to …

Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

It has become widely accepted that inflammation is a driving force behind a variety of
chronic diseases, such as cardiovascular disease, diabetes, kidney disease, cancer …

Metformin (MF), a first-line drug to treat type 2 diabetes mellitus (T2DM), alone and in
combination with other drugs, restores the ovarian function in women with polycystic ovary …

Growth differentiation factor-15 (GDF15) is a member of the GDF subfamily with potential
kidney protective functions. Here, we explored the impact of GDF15 on the expression of the …

Background There are few observational studies evaluating the risk of AKI in people with
type 2 diabetes, and even fewer simultaneously investigating AKI and CKD in this …

OBJECTIVE Metformin is the first pharmacological option for treating type 2 diabetes.
However, the use of this drug is not recommended in individuals with impaired kidney …

Metformin has been extensively used for the treatment of type 2 diabetes, and it may also
promote healthy aging. Despite its widespread use and versatility, metformin's mechanisms …