Breast cancer heterogeneity determines cancer progression, treatment effects, and
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …

p53 is a transcription factor that regulates the expression of genes involved in tumor
suppression. p53 mutations mediate tumorigenesis and occur in approximately 50% of …

The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and
consequences that impact diverse cell types and tissues. Recent studies are beginning to …

The p53 protein, encoded by TP53, is a tumor suppressor that plays a critical role in
regulating apoptosis, cell cycle regulation, and angiogenesis in tumor cells via controlling …

The p53 pathway plays an important role in role in cancer immunity. Mutation or
downregulation of the proteins in the p53 pathway are prevalent in many cancers …

Natural killer (NK) cells play a crucial role in antitumoral and antiviral responses. Yet, cancer
cells can alter themselves or the microenvironment through the secretion of cytokines or …

Increasing evidence suggests that key cancer-causing driver genes continue to exert a
sustained influence on the tumor microenvironment (TME), highlighting the importance of …

Glucocorticoids (GCs), a class of hormones secreted by the adrenal glands, are released
into the bloodstream to maintain homeostasis and modulate responses to various stressors …

Mtp53 对肿瘤免疫的调控及其在免疫治疗中的应用 Page 1 ISSN 1007⁃7626 CN 11⁃3870/Q 中国
生物化学与分子生物学报http:/ / cjbmb. bjmu. edu. cn Chinese Journal of Biochemistry and …

Missense mutations of tumor suppressor genes enable cancerous cells generating variable
mutant proteins and promote malignant development. These mutant proteins lose the …