Chemistry and biology of multicomponent reactions

A Domling, W Wang, K Wang - Chemical reviews, 2012 - ACS Publications
Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

Recent developments in isocyanide based multicomponent reactions in applied chemistry

A Dömling - Chemical reviews, 2006 - ACS Publications
Multicomponent reactions (MCRs) are generally defined as reactions where more than two
staring materials react to form a product, incorporating essentially all of the atoms of the …

The combinatorial synthesis of bicyclic privileged structures or privileged substructures

DA Horton, GT Bourne, ML Smythe - Chemical reviews, 2003 - ACS Publications
The exploration of privileged structures in drug discovery is a rapidly emerging theme in
medicinal chemistry. These structures represent a class of molecules capable of binding to …

" Multi-component reactions: emerging chemistry in drug discovery"'from xylocain to crixivan'

C Hulme, V Gore - Current medicinal chemistry, 2003 - ingentaconnect.com
With the recent emergence of combinatorial chemistry and high-speed parallel synthesis for
drug discovery applications, the multi-component reaction (MCR) has seen a resurgence of …

Recent advances in isocyanide-based multicomponent chemistry

A Dömling - Current Opinion in Chemical Biology, 2002 - Elsevier
Multicomponent reactions (MCRs) provide a powerful tool towards the one-pot synthesis of
diverse and complex compounds on the one hand and small and 'drug-like'heterocycles on …

[图书][B] Isocyanide chemistry: applications in synthesis and material science

V Nenajdenko - 2012 - books.google.com
The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has
resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in …

Isocyanide-based multicomponent reactions for the synthesis of heterocycles

A Váradi, TC Palmer, R Notis Dardashti, S Majumdar - Molecules, 2015 - mdpi.com
Multicomponent reactions (MCRs) are extremely popular owing to their facile execution,
high atom-efficiency and the high diversity of products. MCRs can be used to access various …

Recent developments in use of heteropolyacids, their salts and polyoxometalates in organic synthesis

MM Heravi, S Sadjadi - Journal of the Iranian Chemical Society, 2009 - Springer
Heteropolyacids, their salts and polyoxometalates have been used as catalysts in wide
range of organic reactions such as multi components, oxidation, reductions, electrochemical …

Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry

C Hulme, J Dietrich - Molecular diversity, 2009 - Springer
This review details a now established area within the isonitrile multi-component reaction
(IMCR) field of study, namely employing bi-functional reagents in the Ugi reaction for the …

A versatile synthesis of fused triazolo derivatives by sequential Ugi/alkyne-azide cycloaddition reactions

I Akritopoulou-Zanze, V Gracias, SW Djuric - Tetrahedron letters, 2004 - Elsevier
We report a facile synthesis of fused dihydrotriazolo [1, 5-a] pyrazinones and
triazolobenzodiazepines by an Ugi/alkyne–azide cycloaddition synthetic sequence. The …