It has been one and a half centuries since Enrico Sertoli published the seminal discovery of
the testicular 'nurse cell', not only a key cell in the testis, but indeed one of the most amazing …

For the past decade, cellular oncogenes have attracted the attention of biologists intent on
understanding the molecular origins of cancer. As the present decade unfolds, oncogenes …

Summary in humans, germiine mutations of the WT-7 tumor suppressor gene are associated
with both Wiims' tumors and urogenital malformations. To develop a model system for the …

Denys-Drash syndrome is a rare human condition inwhich severe urogenital aberrations
result in renal fail ure, pseudohermaphroditism, and Wilms' tumor (neph roblastoma). To …

Abstract The Wilms' Tumour gene WT1 has important functions during development. Knock-
out mice were shown to have defects in the urogenital system and to die at embryonic day …

The chromosome 11p13 Wilms tumor susceptibility gene WT1 appears to play a crucial role
in regulating the proliferation and differentiation of nephroblasts and gonadal tissue. The …

In the developing mouse, the Wilms' tumour gene, WT1, is first expressed in the intermediate
mesenchyme lateral to the coelomic cavity (13 somite, early 9 dpc embryo). A few hours …

The homeobox gene Emx2 is a mouse homologue of a Drosophila head gap gene empty
spiracles (ems) and is essential for the development of dorsal telencephalon (Development …

During mouse development, the gonad begins to form shortly before 10.5 days postcoitum
(dpc) on the ventromedial side of the mesonephros. The XY gonad consists of germ cells …

The HMG box family is functionally diverse, with members involved in DNA recognition
during nucleosome assembly, recombination and transcription (1 for review). A subclass of …