Morphogens have been linked to numerous developmental processes, including organ
patterning and the control of organ size. Here we review how different experimental …

Over many years evidence has accumulated that plants and animals can regulate growth
with reference to overall size rather than cell number. Thus, organs and organisms grow …

The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

Orientation of cell divisions is a key mechanism of tissue morphogenesis. In the growing
Drosophila wing imaginal disc epithelium, most of the cell divisions in the central wing …

In most tissues, cell division is coordinated with increases in mass (ie, growth). To
understand this coordination, we altered rates of division in cell clones or compartments of …

Morphogens, such as Decapentaplegic (Dpp) in the fly imaginal discs, form graded
concentration profiles that control patterning and growth of developing organs. In the …

During development, coordinated cell behaviors orchestrate tissue and organ
morphogenesis. Detailed descriptions of cell lineages and behaviors provide a powerful …

Secreted morphogens such as the Drosophila TGF-β homolog Decapentaplegic (Dpp) are
thought to spread through target tissues and form long-range concentration gradients …

A fundamental and unresolved problem in animal development is the question of how a
growing tissue knows when it has achieved its correct final size. A widely held view suggests …

The secreted signaling protein Dpp acts as a morphogen to pattern the anterior–posterior
axis of the Drosophila wing. Dpp activity is required in all cells of the developing wing …