Monoclonal antibodies (mAbs) are subject to instability issues linked to their protein nature.
In this work, we review the different mechanisms that can be linked to monoclonal antibodies …

This review aims to provide an overview of current knowledge on stabilization of proteins by
sugars in the solid state in relation to stress conditions commonly encountered during drying …

Abstract In 1989, Manning, Patel, and Borchardt wrote a review of protein stability (Manning
et al., Pharm. Res. 6: 903–918, 1989), which has been widely referenced ever since. At the …

Abstract Inulin (IN), a fructan-type plant polysaccharide, is widely found in nature. The major
plant sources of IN include chicory, Jerusalem artichoke, dahlia etc. Studies have found that …

Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial
biomaterial and approved medical device used in bone defects with a long track record of …

Lyophilization is a common, but cost-intensive, drying process to achieve protein
formulations with long-term stability. In the past, typical process optimization has focused on …

Developing recombinant protein pharmaceuticals has proved to be very challenging
because of both the complexity of protein production and purification, and the limited …

Trehalose, a disaccharide of glucose, has been reported to accumulate in many organisms
that can withstand extended periods of inanimation. Since this discovery, the properties of …

Abstract Design of freeze-drying processes is often approached with a “trial and error”
experimental plan or, worse yet, the protocol used in the first laboratory run is adopted …

One of the most challenging tasks in the development of protein pharmaceuticals is to deal
with physical and chemical instabilities of proteins. Protein instability is one of the major …