Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …

Tissue vascularization plays a critical role in the regeneration and repair of damaged
tissues. However, in certain instances of tissue injury, the pace and effectiveness of …

Blood vessels grow and remodel in response to mechanical stimuli. Many computational
models capture this process phenomenologically, by assuming stress homeostasis, but this …

Abnormal angiogenesis contributes to the pathogenesis of various diseases. The medicinal
usage of Agrostemma githago L. seed (A. githago herein) has been stated in traditional …

Endothelial cells are key players in the cardiovascular system. Among other things, they are
responsible for sprouting angiogenesis, the process of new blood vessel formation essential …

Introduction The Notch intracellular domain (NICD) and its ligands Jagged-1 (Jag1), Delta-
like ligand (DLL-3) and DLL4 play an important role in neoangiogenesis. Previous studies …

In brief The mechanisms regulating the signaling pathways involved in angiogenesis are not
fully known. Ristori et al. show that Lunatic Fringe (LFng) mediates the crosstalk between …

Cardiac resident macrophages (CRMs) are integral components of the heart and play
significant roles in cardiac development, steady‐state, and injury. Advances in sequencing …

The NOTCH receptors are mechanosensing proteins that require cell-cell contact and
physical force for activation. While most receptors have evolved to respond to one or a few …

Introduction: Several signaling pathways are activated during hypoxia to promote
angiogenesis, leading to endothelial cell patterning, interaction, and downstream signaling …